当血液记住它的性别时:朝着真正个性化的输血医学
Sotirios P Fortis1, Styliani Kokoris2,3, Pavlos Kelepousidis3
1Laboratory of Reliability and Quality Control in Laboratory Hematology (HemQcR), Department of Bio-Medical Sciences, School of Health & Caring Sciences, University of West Attica (UniWA), 12243 Athens, Greece.
性别和性别显著影响输血实践,影响捐赠者的行为,血液产品的特征和患者的结果. 了解这些差异对于在输血治疗中推进精准医学至关重要.
科学领域:
- 输血医学 输血医学
- 精准医学是一门精准的医学.
- 生物医学研究生物医学研究
背景情况:
- 生物性别差异是精准医学中的关键因素.
- 性影响蛋白质表达,信号传递和细胞通路.
- 人们越来越认识到性别和性别在输血医学中的作用.
研究的目的:
- 审查整个输血链中性别和性别的作用.
- 评估来自观察性研究,注册表分析和随机试验的数据.
- 总结关于输血医学中性别/性别影响的当前知识.
主要方法:
- 对现有文献进行系统审查.
- 从观察性研究中分析数据.
- 包括注册表分析和随机对照试验.
主要成果:
- 女性捐赠者有较高的延期率,但是更一致的捐赠者.
- 男性捐赠者提供红细胞具有更高的血红蛋白;女性捐赠者的红细胞具有更好的存储稳定性.
- 多胎妇女的血可能含有与输血反应 (TRALI) 相关的抗体.
- 性别不匹配的输血在大型试验中显示出对患者结果的不一致影响.
结论:
- 输血实践中,捐赠者和接受者的性别是重要的变量.
- 基于性别的策略可以提高输血安全性和精准医学.
- 需要进一步的研究才能充分理解和应用输血中的性别特异性见解.
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