生物标志物 生物标志物
Arunima Kapoor1, Shubir Dutt2,3, John Paul M Alitin1
1University of California, Irvine, Irvine, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
较高的脑血管反应率 (CVR) 显著降低了周周血管空间 (ePVS) 扩大和白质超强度 (WMH) 的风险. 心血管回路逆差可能表明早期的大脑小血管疾病变化,突出显示心血管回路作为潜在的风险标志物.
科学领域:
- 神经学 神经学
- 放射学 放射学是指放射学
- 老年学是指老年学的学科.
背景情况:
- 扩大周血管空间 (ePVS) 和白质超强度 (WMH) 在大脑小血管疾病中很常见.
- 很少有研究研究了脑血管功能障碍对ePVS和WMH的独立影响.
- 大脑血管活性 (CVR) 是大脑血管功能的早期标志物.
研究的目的:
- 为了检查没有ePVS/WMH,只有ePVS,只有WMH,以及ePVS和WMH的个体之间的CVR差异.
- 确定大脑血管功能受损是否会增加患EPVS和WMH的风险.
- 评估CVR与ePVS和WMH存在之间的关联.
主要方法:
- 招募了118名非痴呆症,非中风的老年人 (平均年龄68.4岁).
- 使用pCASLMRI在呼吸练习诱导的头增大期间量化全脑CVR.
- 使用标准化MRI评分尺度 (中心半圆和Fazekas尺度) 评估ePVS和WMH.
主要成果:
- 在两组之间发现了CVR的显著差异 (p=.021).
- 患有ePVS和WMH的个体的CVR显著降低,相比于没有两者的人.
- 较高的CVR与联合ePVS和WMH的风险降低有关 (OR=0.78,p=.035),即使调整了年龄和性别.
结论:
- 较高的CVR与联合ePVS和WMH的风险明显降低有关.
- 心血管回路赤字可能代表早期的病理变化,有助于ePVS和WMH的发展.
- 进一步的研究应该探索区域CVR差异及其对认知功能的影响.
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