在前列腺癌患者中评估前列腺癌风险的不同代谢概况
Tuo Liu1, Jahnvi Roorkeewal2, Melissa A Furlong1
1Department of Community, Environment, and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.
Metabolites
|December 24, 2025
概括
尿路代谢物显示出区分高度前列腺癌 (PCa) 和低度PCa的潜力,为风险分层提供超出前列腺特异性抗原 (PSA) 的新生物标志物.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢学 代谢学 代谢学
- 在瘤学瘤学.
背景情况:
- 目前前前列腺癌 (PCa) 风险分层严重依赖前列腺特异性抗原 (PSA),缺乏经过验证的生物标志物.
- 对于新型生物标志物来准确评估PCa的攻击性是非常需要的.
研究的目的:
- 为了确定与高等级PCa相关的特定尿液代谢物.
- 探索这些代谢物作为PCa风险分层的生物标志物的潜力.
主要方法:
- 分析了22名经过激进前列腺切除术的患者的尿液样本.
- 使用液态染色体质谱法 (LC-MS) 在逆相 (RP) 和水友相互作用染色体 (HILIC) 两种模式的高分辨率代谢学.
- 进行了差异代谢物分析和途径丰富分析.
主要成果:
- 在高级和低级PCa组之间确定了52种不同的代谢物 (p<0.05).
- 甲基α-阿斯帕提尔氨酸和3-甲基butan酸显示出显著的差异化.
- 希斯蒂丁代谢途径显著丰富,观察到B维生素途径的改变.
结论:
- 尿路代谢产物可能有能力区分高级PCa和低级PCa.
- 代谢重编程与PCa攻击性相关.
- 研究结果表明PCa进展与饮食模式之间存在潜在联系.
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