对肠道微生物群和肠道细胞的微塑性毒性:来自人类肠道微生物生态系统模拟器 (SHIME) 的证据
Xingchao Ren1, Chen Su1, Yuyan Zhu1,2
1Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
Toxics
|December 24, 2025
概括
聚烯微塑料 (MP) 破坏肠道细菌,减少有益的短链脂肪酸 (SCFA). 这会影响肠道健康,可能导致全身毒性和线粒体问题.
科学领域:
- 环境健康 环境健康
- 微生物组研究 微生物组研究
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料 (MP) 是普遍存在的环境污染物,越来越多的证据表明它们对人类健康有不良影响.
- 胃肠道是MP通过摄入,吸入或皮肤接触进入人体的主要途径.
研究的目的:
- 研究聚钢 (PS) 微塑料对肠道微生物群组成和短链脂肪酸 (SCFA) 代谢的影响.
- 评估PS MPs对人类肠道细胞模型的影响.
主要方法:
- 利用人类肠道微生物生态系统模拟器 (SHIME) 来建模人类结肠.
- 分析了微生物多样性,Firmicutes/Bacteroidetes比率,以及SCFA产量.
- 暴露了一个共同培养的肠道细胞模型 (Caco-2/HT29-MTX-E12) 给SHIME超级生物.
主要成果:
- 观察到肠道微生物多样性的区域和个体特异性变化.
- 检测到Firmicutes/Bacteroidetes比率的显著变化,以及像Bifidobacteriaceae这样的有益细菌的减少.
- 在肠道细胞模型中证明了增强的氧化应激和线粒体功能障碍,而不会影响屏障完整性或粘液分泌.
结论:
- 聚乙烯微塑料可以通过肠道微生物介导的途径诱导全身毒性.
- 调查结果强调了与微塑料暴露相关的潜在健康风险以及缓解策略的必要性.
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