对前列腺特异性抗原和内皮标记物的影响:前列腺损伤的风险
Servet Birgin İritaş1, Melih Gaffar Gözükara2, Lütfiye Tutkun3
1Department of Forensic Medicine, Faculty of Medicine, Ankara Yildirim Beyazit University, 06800 Ankara, Türkiye.
Toxics
|December 24, 2025
概括
长期接触有毒 (Cd) 的职业暴露会破坏甲基化的代谢,并提高前列腺特异性抗原 (PSA) 水平,这表明血管和前列腺应激的代谢途径是共同的.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- (Cd) 是一种在人体组织中生物积累的持久性有毒金属.
- CD暴露与内皮和前列腺功能障碍有关,但代谢机制尚不清楚.
- 职业Cd暴露需要对其代谢影响进行调查.
研究的目的:
- 调查慢性职业Cd暴露是否会改变甲基化氨酸代谢和前列腺特异性抗原 (PSA) 水平.
- 探索一个潜在的共享毒性代谢轴,将CD暴露与血管和前列腺压力联系起来.
- 为了确定Cd相关代谢损伤的潜在早期生物标志物.
主要方法:
- 研究包括150名男性工人 (75名Cd暴露的金工人,75名对照者),所有这些都是非吸烟者.
- 使用诱导合等离子体质谱法 (ICP-MS) 量化尿液Cd.
- 使用LC-MS/MS和电化学发光来测量血清不对称二甲氨酸 (ADMA),对称二甲氨酸 (SDMA),L-氨酸,氨酸和PSA.
主要成果:
- 暴露于Cd的工人显示尿液中的Cd,PSA,ADMA和SDMA水平显著上升.
- 暴露工人的阿金/ADMA比率降低表明氧化生物可用性受损.
- 尿中的Cd与PSA和ADMA水平升高有很强的相关性.
结论:
- 长期的职业Cd暴露会破坏氧化通路并增加PSA.
- 这些发现支持Cd暴露,血管应激和前列腺应激之间的机械联系.
- 结合ADMA,SDMA和PSA分析可能成为Cd相关代谢损伤的早期生物标志物.
关键词:
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