Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.8K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

CAR T-Cell Therapy for Cancer: Updates and Challenges for Response Assessment.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Compact breast parenchyma: imaging and transcriptomic correlates.

Journal of translational medicine·2026
Same author

Long-standing Large Nonfunctional Cardiac Paraganglioma.

Radiology. Imaging cancer·2026
Same author

Comparative analysis of lung-RADS 2022 and Fleischner's 2017 guidelines.

Clinical imaging·2026
Same author

Cardiac MRI of a Left Ventricular Intramyocardial Suspected Hydatid Cyst.

Methodist DeBakey cardiovascular journal·2025
Same author

Emerging PET Imaging Agents and Targeted Radioligand Therapy: A Review of Clinical Applications and Trials.

Tomography (Ann Arbor, Mich.)·2025

相关实验视频

Updated: Jan 7, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

5.0K

癌症相关纤维细胞:在成像和治疗中的临床应用.

Neda Nilforoushan1, Ashkan Khavaran2,3, Maierdan Palihati1

  • 1Department of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Tomography (Ann Arbor, Mich.)
|December 24, 2025
PubMed
概括

与癌症相关的纤维细胞 (CAFs) 驱动瘤的进展. 针对CAF的纤维细胞激活蛋白 (FAP) 为癌症成像和治疗提供了新的途径,目前正在进行临床研究.

关键词:
与癌症相关的纤维细胞 (CAFs).纤维细胞激活蛋白 (FAP) 是一种激活蛋白.不同质性的异质性图像成像生物标记物放射性合物治疗疗法向着树叶的向瘤微环境 (TME) 是指瘤的微环境.

更多相关视频

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

803
Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
08:02

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

6.4K

相关实验视频

Last Updated: Jan 7, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

5.0K
Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

803
Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
08:02

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

6.4K

科学领域:

  • 在瘤学瘤学.
  • 瘤 微环境 生物学
  • 癌症治疗方法 癌症治疗方法

背景情况:

  • 癌症相关纤维细胞 (CAFs) 是瘤微环境的关键组成部分,通过矩阵重塑,免疫逃避,血管生成和转移来影响瘤的进展.
  • 纤维细胞激活蛋白 (FAP) 在许多固体瘤中高度表达在CAF的子集上,与预后不佳有关.
  • FAP正在成为新型癌症成像和治疗策略的重要目标.

研究的目的:

  • 在瘤微环境中对CAF进行临床专注的审查.
  • 要突出关键的纤维细胞标记物,它们的预后关联,以及它们在成像和向治疗中的实用性.
  • 探索针对CAF的新兴策略,包括非FAP分子和特定亚型的方法.

主要方法:

  • 关于CAFs,FAP表达和向固体瘤的向策略的文献综述.
  • 纤维细胞标志物与癌症结局之间的预后关联的分析.
  • 检查目前针对FAP向剂的临床前和临床研究.

主要成果:

  • CAFs表现出多种不同的亚型,在促进瘤生长和扩散方面发挥着关键作用.
  • 升高的FAP水平与许多癌症类型的不良预后相关.
  • 在癌症治疗和成像方面,正在研究多种FAP向模式.

结论:

  • 在固体瘤中,FAP是一个有前途的治疗和成像标.
  • 针对CAF,特别是通过选择性和亚型特定的策略,有可能促进癌症治疗.
  • 放射性成像和向性 stromal 疗法是在瘤学的不断发展的领域.