从成年人一生中CT细分的身体图表:大规模的截面和纵向分析
Christian Wachinger1, Bernhard Renger1, Christopher Späth1
1Department of Diagnostic and Interventional Radiology, TUM Klinikum, School of Medicine and Healthy, Technical University of Munich, Ismaningerstr. 22, 81675 Munich, Germany.
Radiology. Artificial intelligence
|December 24, 2025
概括
这项研究为成年人开发了基于CT的全身解剖体积图. 这些图表模拟了与年龄相关的变化和性别差异,有助于量化个体偏差.
科学领域:
- 放射学和医学成像学 医学成像学
- 生物统计学 生物统计学
- 人类解剖学 人类解剖学
背景情况:
- 缺乏成年人解剖体积的非大脑CT全身标准.
- 需要全面的横截面和纵向参考数据.
研究的目的:
- 为了模拟成年期CT衍生的全身解剖体积.
- 建立成年人解剖学的横截面和纵向参考图表.
- 为解决非大脑CT全身标准的缺陷.
主要方法:
- 利用多个数据集 (超过10万名患者) 的回顾式CT扫描.
- 采用了104个解剖结构的自动细分和自动质量控制管道.
- 应用的位置,尺度和形状 (GAMLSS) 的通用化添加模型和通用化添加混合模型 (GAMM),用于横截面和纵向分析.
主要成果:
- 所有解剖结构都表现出复杂的,非线性年龄轨迹,具有显著的性别差异.
- 在血管结构上观察到CT对比效应.
- 引导重新抽样证实了体积轨迹的稳定性;心壮病分析显示心脏体积百分点得分增加.
结论:
- 开发了成年人CT衍生的解剖体积的横截面和纵向参考模型.
- 这些模型绘制了整个成年期身体结构变化的轨迹.
- 开发的体图允许使用百分比得分对单个偏差进行可靠的量化.
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