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通过纳米钻石量子磁力学探测细胞下动作潜力的方法.

Azmath Fathima^1,2, Peker Milas^1,3, Sheikh Mahtab¹

¹Department of Physics and Engineering Physics, Morgan State University, Baltimore, MD 21251, USA.

Nanomaterials (Basel, Switzerland)

|December 24, 2025

概括

空位 (NV) 纳米钻石在小鼠大脑细胞中作为非漂白的光标记物. 这些纳米钻石显示出潜在的亚细胞动能记录潜力,推进量子传感应用.

关键词:

在NV钻石.这是ODMR ODMR.行动潜力行动潜力量子传感是一种量子感应.

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科学领域:

量子传感是一种量子感应.
纳米技术纳米技术
神经科学是一个神经科学.

背景情况:

钻石中的空位 (NV) 缺陷是各种物理量强大的量子传感器.
大量钻石中的NV缺陷使生物系统中的动作潜能检测成为可能.
具有NV缺陷的纳米钻石 (ND) 是非漂白的光标记物,但亚细胞动力潜力的记录仍然未实现.

研究的目的:

调查使用纳米钻石 (NDs) 在小鼠大脑细胞中进行亚细胞成像和传感的可行性.
评估NDs在亚细胞水平上记录动作潜力的潜力.

主要方法:

使用焦点对照成像来跟踪不同大小的ND (10-140nm) 的细胞吸收.
光发光 (PL) 稳定性在5小时的成像过程中进行了评估.
光学检测磁共振 (ODMR) 用于在细胞溶液中使用ND检测磁场.

主要成果:

10nm和60nm的NDS在30分钟内扩散到小鼠大脑细胞中,而不会改变表面.
在长时间的成像期间,NDs表现出稳定的,非漂白的光发光.
在细胞环境中,ODMR成功地检测了具有ND的千米级磁场.

结论:

NDs是对小鼠大脑细胞有效的,光稳定的光标记物.
在亚细胞动力潜力记录中,ND显示了未来应用的潜力.
这项工作推动了量子传感工具在神经科学研究中的应用.