相关实验视频
Updated: Jan 7, 2026
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
21.6K
作为单克隆抗体诱导的甲状腺轨道病变的治疗方法,teprotumumab的病例报告
Jared Moon1, Nicole Duncan1, Jeff Yorio2
1Mitchel and Shannon Wong Eye Institute, Department of Ophthalmology, Dell Medical School at the University of Texas at Austin, Austin, TX 78712, USA.
Reports (MDPI)
|December 24, 2025
概括
单克隆抗体 (mAbs) 可以导致罕见的甲状腺眼病 (TED). 提普鲁马布有效地治疗了两名患有二次mAb治疗后的耐固醇TED患者,提供了一种新的治疗选择.
科学领域:
- 免疫学 免疫学 免疫学
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
背景情况:
- 单克隆抗体 (mAbs) 对于治疗癌症和自身免疫性疾病至关重要.
- 免疫相关不良事件 (IRAE),包括轨道病变,是mAb治疗的罕见但严重的并发症.
- 对mAbs次要的甲状腺眼病 (TED) 很少报告,特别是耐火病例.
研究的目的:
- 在单克隆抗体 (mAb) 治疗后报告两例甲状腺眼病 (TED).
- 为了评估teprotumumab在mAbs引起的类固醇耐火TED中的疗效.
- 提高人们对与mAb治疗相关的轨道并发症的认识.
主要方法:
- 一个73岁的妇女的病例报告用尼沃卢马布治疗黑色素瘤.
- 一名36岁的男子因多发性硬化症而接受阿勒姆图祖马布治疗的病例报告.
- 这两名患者都接受了针对耐火性甲状腺眼病 (TED) 的teprotumumab治疗.
主要成果:
- 两名患者在接受单克隆抗体 (mAb) 治疗后出现甲状腺眼病 (TED).
- 最初的皮质类固醇治疗对这两名患者都是无效的.
- 在teprotumumab治疗后,TED的显著改善被观察到.
结论:
- 单克隆抗体 (mAb) 治疗可能导致未被认可的轨道免疫相关不良事件 (IRAE),如甲状腺眼病 (TED).
- 德鲁马布显示承诺作为一种有效的治疗类固醇耐火性甲状腺轨道病的二次到mAb治疗.
- 需要提高临床意识和进一步的研究来管理mAb相关的轨道病变.
相关概念视频
01:27Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
01:23The Thyroid Gland
6.5K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.5K
01:20Synthesis and Regulation of Thyroid Hormones
7.0K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.0K