双边无菌眼内炎症 继内内阿弗利塞普特8毫克注射后:一个病例报告
Ram Cohen1, Tomer Kerman1, Omer Trivizki1,2
1Department of Ophthalmology, Tel Aviv Sourasky Medical Center, University of Tel Aviv, Tel Aviv 64239, Israel.
Reports (MDPI)
|December 24, 2025
概括
在高剂量aflibercept注射 (Eylea HD) 后,双边无菌眼内炎可能发生. 在这种情况下,用皮质类固醇迅速治疗导致了症状的快速消失.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 是导致视力丧失的主要原因.
- 内抗VEGF治疗是对nAMD的标准治疗方法.
- 阿弗利伯塞普特8毫克 (Eylea HD) 是阿弗利伯塞普特的高剂量配方.
研究的目的:
- 报告双边无菌眼内炎症的病例,该病例是在静脉内注射aflibercept 8 mg后发生的.
- 突出这一不良事件的临床表现和管理.
- 强调识别无菌炎症的重要性,以避免误诊.
主要方法:
- 一个89岁的女性患有双边nAMD的病例报告.
- 临床检查包括前段和玻璃体评估.
- 乙扫描超声波,以评估视网膜状态.
- 用局部皮质类固醇,抗生素和循环治疗的治疗.
主要成果:
- 患者在注射后四天出现双边视力模糊和眼睛疼痛.
- 检查显示显著的前腔反应和玻璃体炎症.
- 无菌眼内炎的诊断是基于临床表现和病史.
- 在治疗四天内出现了快速改善和症状消失.
结论:
- 内阿弗利塞普特8毫克可以引起双边无菌眼内炎症.
- 这种不良事件甚至可以发生在耐受较低剂量的患者中.
- 及时识别和使用皮质类固醇的治疗对于有利的结果至关重要.
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