相关实验视频

Updated: Jan 7, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

探索视神经头部的结构和血管变化,在初级开放角玻璃眼中进行带切除术后

Francesco Cappellani^1,2, Niccolò Castellino², Marco Zeppieri^3,4

¹Department of Medicine and Surgery, University of Enna "Kore", Piazza dell'Università, 94100 Enna, Italy.

Vision (Basel, Switzerland)

|December 24, 2025

概括

带切除手术显著降低了眼内压力 (IOP),导致视神经头部 (ONH) 的部分结构恢复,并改善了青光眼患者的深视网膜血管密度.

科学领域:

眼科医生眼科眼科
玻璃眼研究研究玻璃眼研究
手术干预手术干预

背景情况:

垂眼切除术 (trabeculectomy) 是用于控制眼内压力 (IOP) 的绿眼病的标准手术治疗方法.
轨道切除术对视神经头部 (ONH) 形态和视网膜微血管结构的影响需要进一步澄清.
这项研究使用先进的OCT成像技术研究了trabeculectomy后的结构和血管变化.

研究的目的:

评估轨道切除术对ONH结构和视网膜微血管结构的影响.
在IOP降低后,评估光盘缩和血管密度的变化.
了解在绿眼病管理中的机械和血管因素之间的相互作用.

主要方法:

追溯分析了22名接受带切除术的初级开角绿眼患者.
使用光谱域光学连贯性断层扫描 (SD-OCT) 和OCT血管学 (OCTA) 的术前和术后两个月数据的比较.
测量结构参数 (BMO,MCD,杯面积) 和血管密度 (VD) 在光盘,周和黄斑区域.

主要成果:

带切除术显著降低了平均内血压从23.1mmHg降至13.2mmHg (p < 0.001).
手术后观察到BMO,最大杯深 (MCD) 和杯面积的显著减少 (p < 0.001).
深层毛细管 (DCP) 血管密度在和区域增加,而表面毛细管 (SCP) 保持稳定.

结论:

椎间盘切除术促进ONH的部分结构恢复,通过在IOP降低后逆转光盘缩.
观察到的深视网膜血管密度的增加表明,对IOP降低的层特异性微血管反应.
这些发现有助于更好地了解青光眼的机制,并可能指导术后监测策略.

关键词:

布鲁赫的膜打开了开口.有关OCT的血管学.玻璃眼 glaucoma 玻璃眼玻璃眼玻璃眼玻璃眼拉米娜·克里布罗萨 (Lamina Cribrosa) 是一个视神经的头部视神经的头部光学连贯性断层扫描 (optical coherence tomography) 是一种光学连贯性断层扫描技术.视网膜微血管学形切除术的方法是:船舶密度是指船舶的密度.

更多相关视频

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

相关概念视频

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...