[由于化物引起的手部疼痛和指部胀:沃里可纳诱导的周节炎]
J F Schouten1,2, C G Ter Meulen1, C Kramers1
1Canisius Wilhelmina Ziekenhuis, afd. Klinische farmacie, Nijmegen.
Nederlands tijdschrift voor geneeskunde
|December 24, 2025
概括
沃里康纳治疗可能会导致骨周炎,一个疼痛的骨状况,在接受血液透析的患者. 切换到波萨可纳可以缓解症状,这凸显了监测药物诱导的骨并发症的重要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 类风湿病学 类风湿病学
背景情况:
- 沃里可纳是一种广泛使用的抗真菌药物.
- 患有慢性病的血液透析患者可能会改变药物的新陈代谢和分泌.
- 乳炎是一种罕见但严重的副作用,与沃里康纳治疗有关.
研究的目的:
- 在血液透析的患者中报告一例沃里可纳诱导的周节炎.
- 突出诊断挑战和管理这种罕见的不良影响.
- 强调在患有无法解释的骨疼痛的患者中考虑药物毒性的重要性.
主要方法:
- 一个临床案例介绍一个67岁的女性在血液透析.
- 审查实验室发现,包括性酸酶和血清化物水平.
- 放射性成像,以评估周骨反应.
- 在改变药物后对症状进行临床监测.
主要成果:
- 患者呈现出持续的手部疼痛和胀.
- 性酸酶升高和成像检测结果表明皮质炎.
- 高血清化物水平证实了沃里康纳的毒性.
- 在切换到波萨可纳后,症状迅速消失.
结论:
- 沃里康纳醇诱导的周周炎是血液透析患者的潜在并发症.
- 监测血清化物水平和放射学变化对于诊断至关重要.
- 波萨可纳作为一种可行的替代治疗选择,导致症状消失.
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