生物标志物 生物标志物
Faiza G Durrani1, Charles R Marshall2, Sheena Waters2
1Queen Mary University of London, London, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
听觉认知测试显示,早期发现阿尔茨海默病 (AD) 是有前途的,有助于痴呆风险分层. 这项研究评估了数字听觉评估与生物标志物相结合,以获得准确和可访问的大脑健康评估.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 阿尔茨海默氏病 (AD) 与听觉功能障碍有关,特别是语音噪音感知障碍.
- 较差的听觉功能与认知能力下降和AD易受伤害的大脑区域灰质减少有关.
- 听觉认知可以作为早期大脑健康评估和痴呆风险分层的成本效益高的工具.
研究的目的:
- 评估听觉感知功能评估与血液生物标志物一起用于早期痴呆症诊断的实用性.
- 开发一种可扩展的数字测试,用于中央听觉处理,作为早期痴呆症诊断工具 (DIADEM研究).
- 评估听觉认知对临床诊断,认知衰退和认知症状患者痴呆症进展的预测价值.
主要方法:
- 从17个NHS记忆诊所招募了600名参与者,其中包括100名健康对照.
- 使用语音噪音,语音退化和言语声测试,纯音声测量,认知评估 (CDR,RUDAS/MMSE),血液生物标志物 (pTau-217,NfL) 和MRI.
- 随访两年,定期评估认知和听觉功能.
主要成果:
- 概念验证在区分AD患者与健康对照者和跟踪疾病进展方面表现出高准确性 (AUC0.91).
- 评估单独和生物标志物 (pTau217,NfL) 的听觉感知测试,用于诊断和预后的认知症状的个体.
- 审查数字审计评估方法的文化公平性和成本效益.
结论:
- 开发基于听觉认知测量的可扩展,文化公平和精确的数字工具可以彻底改变早期痴呆症诊断.
- 改善获得及时和公平的痴呆症诊断的机会.
- 支持认知症状和潜在痴呆症患者的早期治疗和护理干预措施.
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