疫苗平台依赖于微生物群多样性的差异影响:蛋白质子单位疫苗的潜在优势
Hye Seong1,2, Jin Gu Yoon2,3, Eliel Nham2,3
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Vaccines
|December 24, 2025
概括
在接种疫苗后,蛋白质子单元疫苗NVX-CoV2373提高了肠道微生物群的多样性. 这与mRNA和腺病毒载体疫苗形成鲜明对比,mRNA和腺病毒载体疫苗显示肠道细菌多样性的减少或没有显著变化.
科学领域:
- 微生物组研究的研究.
- 疫苗学 疫苗学 疫苗学
- 免疫学 免疫学 免疫学
背景情况:
- 随着COVID-19的流行,mRNA,腺病毒载体和蛋白质亚单元疫苗的开发得到了刺激.
- 人们越来越认识到肠道微生物群在疫苗反应中的作用.
- 这项研究调查了不同COVID-19疫苗平台对肠道微生物群多样性后增强后的影响.
研究的目的:
- 为了比较蛋白质亚单元 (NVX-CoV2373),mRNA (BNT162b2) 和腺病毒载体 (ChAdOx1) 疫苗对肠道微生物群多样性的影响.
- 评估在增剂接种疫苗后的α多样性和特定细菌种群的变化.
主要方法:
- 对35名健康成年人接受NVX-CoV2373助推剂的前性队列研究.
- 便和血液样本是在接种疫苗前和接种疫苗后三周收集的.
- 与之前的mRNA和腺病毒载体疫苗队伍相比,用于肠道微生物组概况的16SrRNA基因测序.
主要成果:
- NVX-CoV2373助推剂显著增加了肠道微生物群的α多样性 (香农指数,p=0.027).
- 这与腺病毒载体疫苗 (持续的α多样性减少) 和mRNA疫苗 (暂时上升,然后下降) 相反.
- NVX-CoV2373增加了有益的种群 (例如, Bacteroides fragilis) 并减少了Prevotella bivia.
结论:
- 蛋白质子单元疫苗NVX-CoV2373在增强剂环境中对肠道微生物群多样性产生有利影响.
- 它对增加α多样性的作用不同于使用mRNA和腺病毒载体增强剂观察到的模式.
- 研究结果强调了微生物群对不同疫苗平台的不同反应.
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