生物标志物 生物标志物
Wenzhi Shi1, Peiyao Wei1, Juanjuan Lu1
1Shaanxi Provincial People's Hospital, Xi'an, Shaanxi Provincial, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
LDL-C/ApoB比率是LDL颗粒大小的标志物,是老年人心血管事件 (CI) 的重要危险因素. 保持最佳比率可能对预防CI至关重要.
科学领域:
- 心血管医学 心血管医学
- 脂质代谢 脂质代谢是什么
- 老年人的健康 老年人的健康
背景情况:
- 升高的Apolipoprotein B (ApoB) 和LDL-C水平与心血管事件 (CI) 有关.
- LDL-C/ApoB比率表明LDL颗粒的大小;较小,更密集的LDL (sdLDL) 颗粒更具有异性.
- 确切的LDL-C/ApoB比率与CI之间的关系需要进一步阐明.
研究的目的:
- 研究60岁以上个体的LDL-C/ApoB比率与心血管事件 (CI) 之间的关联.
- 探索LDL-C/ApoB比率与CI之间的潜在非线性关系.
主要方法:
- 利用了2011-2014年国家健康和营养检查调查 (NHANES) 的数据.
- 包括1105名60岁以上的参与者.
- 使用后勤回归和限制立方线 (RCS) 分析.
主要成果:
- 后勤回归显示,LDL-C/ApoB比率与CI (OR:1.519,p < 0.001) 之间存在显著的关联,但不仅仅是ApoB (OR:1.003,p = 0.215).
- 在对年龄和性别进行调整后,这些发现仍然存在 (OR: 1.349,p < 0.05).
- RCS分析表明,即使在调整后,LDL-C/ApoB比率和CI (P非线性<0.0001) 之间存在显著的非线性关系.
结论:
- 确定LDL-C/ApoB比率是老年人群中CI的潜在风险因素.
- 一个最佳的LDL-C/ApoB比率可能在预防心血管事件中起到至关重要的作用.
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