生物标志物 生物标志物
Meina Quan1,2,3,4, Yazhen Huang1, Bote Zhao1
1Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
血炎症生物标志物,包括中性粒细胞与淋巴细胞比率 (NLR),有助于诊断阿尔茨海默氏症痴呆症 (ADD) 并将其与其他神经退行性疾病区分开来. 这些标记物与大脑脊髓液 (CSF) 与阿尔茨海默病生物标记物相关.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 阿尔茨海默病痴呆症 (ADD) 诊断可能具有挑战性,特别是将其与其他神经退行性疾病区分开来.
- 脑脊液 (CSF) 生物标志物已经确立,但具有侵入性;探索基于血的标志物至关重要.
研究的目的:
- 调查ADD和其他神经退行性痴呆症 (非ADD) 的血炎症生物标志物.
- 评估血炎症标志物和CSF阿尔茨海默氏病生物标志物之间的关联.
- 评估ADD等离子体炎症标志物的诊断和差异诊断值.
主要方法:
- 分析了来自两个队列的245名和328名参与者,包括对照组,ADD和非ADD组.
- 测量CSF生物标志物 (Aβ42,ptau181,ttau) 和血炎症标志物 (中性细胞,淋巴细胞,血小板计数,CRP,白蛋白).
- 统计分析以确定预测性能和相关性.
主要成果:
- 脑液生物标志物比率,炎症比率和ApoE4的组合有效地将ADD与对照区分开来.
- 一个特定的组合,包括CSF比率,中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR) 和ApoE4,将ADD与NonADD区分开来.
- 血炎症标志物,特别是NLR,在ADD患者中与CSFAD生物标志物呈正相关性.
结论:
- 血炎症生物标志物为ADD的诊断提供了显著的附加值.
- 这些标记物在ADD与其他神经退行性疾病的差异诊断中也很有价值.
- 作为与AD病理学相关的可访问指标,NLR和PLR显示出希望.
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