生物标志物 生物标志物
Ansar A1, Athira B1, Rubell Marion Lincy G1
1Indian Institute of Information Technology, Kottayam, Kottayam, Kerala, India.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
视网膜血管结构的碎形维度 (FD) 分析显示,阿尔茨海默病 (AD) 患者的值与对照人群相比显著较低. 这表明FD可以作为早期AD检测的潜在生物标志物.
科学领域:
- 眼科医生 眼科 眼科
- 医学成像分析 医学成像分析
- 神经学 神经学
背景情况:
- 自动视网膜血管细分对于诊断阿尔茨海默氏症等疾病至关重要.
- 本研究引入了一种使用半监督域调整和多教师-学生 (MTSC) 协作用于视网膜图像细分和碎形维度 (FD) 计算的新框架.
研究的目的:
- 开发和验证基于MTSC的新型框架,用于精确的视网膜血管细分.
- 调查从视网膜血管结构计算FD作为阿尔茨海默病 (AD) 潜在生物标志物的实用性.
主要方法:
- 利用公共的DRIVE数据集,从AD患者和正常对照组收集视网膜图像.
- 实施了多教师-学生 (MTSC) 架构,以协作关注和双重监督进行细分.
- 提取了视网膜血管并计算了它们的碎形尺寸 (FD).
主要成果:
- 在细分方面实现了高性能,精度为 (0.9786),IoU (0.8406),AUC (0.9206) 和F1-Score (0.8688).
- 与正常对照组 (1.46-1.60) 相比,AD患者的FD值显著较低 (0.84-1.32).
- 在AD患者和对照人群之间,FD的差异是统计学上显著的 (p=0.000048).
结论:
- 视网膜血管结构的碎形维度 (FD) 可以作为预测阿尔茨海默病的宝贵生物标志物.
- 在AD患者中,较低的FD值表明与该疾病相关的视网膜血管结构的潜在结构变化.
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