生物标志物 生物标志物
Julia R Zickus1,2, José S Enriquez1,2, Muxin Wang1,2
1University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
超极化MRI显示阿尔茨海默氏症患者的葡萄糖代谢减少.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 医疗成像医学成像
背景情况:
- 阿尔茨海默病 (AD) 与葡萄糖代谢受损有关,这是一个潜在的诊断生物标志物.
- 超极化 (HP) 酸盐MRI可使代谢途径成像效果提高1万倍以上.
- 开发早期诊断生物标志物和成像工具对于AD治疗发展至关重要.
研究的目的:
- 使用HP-MR. 在阿尔茨海默病 (AD) 鼠标模型中实体内检查代谢变化.
- 评估酸盐到乳酸盐的实时转化,作为AD中的糖解活性标记物.
- 在AD模型中将代谢变化与衰老和疾病进展相关联.
主要方法:
- 动态核极化 (DNP) 超极化的1-C酸盐被用于实体内测量实时代谢.
- 在AD小鼠模型中,7T MRI动物扫描仪被用于在多个时间点的体内成像.
- 通过核磁共振 (NMR) 光谱进行了ex vivo代谢对切除的大脑组织.
主要成果:
- 在AD模型小鼠中观察到乳酸与酸盐的比率下降,这表明糖解活性降低.
- 在老年AD小鼠中发现大脑代谢物的显著减少,包括胆,肌酸,酸盐,谷氨酸和N-乙酸 (NAA).
- 在年轻的Tau小鼠模型中观察到类似的代谢物减少,这表明早期的变化.
结论:
- 乳酸与酸盐的比率作为AD小鼠模型中改变的糖溶性活性的敏感指标.
- 代谢变化,包括减少糖解和特定代谢物变化,与阿尔茨海默病的衰老有关.
- 惠普-MR和代谢学表明,它有望检测AD相关的代谢变化,支持进一步的验证和治疗研究.
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