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磁力共振成像引导的肌肉活检改善了中小血管血管炎的诊断产量:一项回顾性单中心研究

Soma Fukami¹, Shin-Ichiro Ohmura², Takayuki Masui³

¹Department of Rheumatology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Chuo-ku, Hamamatsu, Shizuoka, Japan.

Rheumatology international

|December 24, 2025

概括

磁共振成像 (MRI) 引导的肌肉活检 (MB) 显示了小至中型血管血管炎的高诊断灵敏度,包括抗中性细胞质抗体相关血管炎 (AAV) 和多关节炎 (PAN). 即使没有肌肉疼痛或其他部位不适合,这种技术也很有价值.

科学领域:

类风湿病学类风湿病学
诊断成像诊断成像诊断成像
病理学病理学病理学

背景情况:

小到中型血管血管炎,包括抗中性粒细胞质抗体相关血管炎 (AAV) 和多关节炎 (PAN),存在诊断挑战.
肌肉活检 (MB) 是一个关键的诊断工具,但其与高级成像指导的实用性需要评估.

研究的目的:

为了评估磁共振成像 (MRI) 引导的肌肉活检 (MB) 对中小血管血管炎的诊断灵敏度.
评估MRI指导的MB在诊断AAV和PAN方面的有效性.

主要方法:

在2020年4月至2025年3月期间接受了MRI和MB的18名AAV或PAN患者的回顾性分析.
根据死性或非死性血管炎的组织学发现,评估诊断灵敏度.

主要成果:

在MRI指导的MB中,AAV和PAN组合的诊断灵敏度为83.3% (15/18名患者).
对于单独的PAN,诊断灵敏度为85.7% (6/7名患者).
没有发生与活检相关的并发症,结果与肌肉疼痛或肌酸酶水平无关,结果相似.

结论:

磁力共振导向的MB是小到中型血管血管炎的潜在有价值的诊断选择.
这种方法即使在缺乏典型症状 (如肌肉疼痛) 的情况下也有效,或者当替代活组织部位无法使用时也有效.
建议在更大,前性,多中心研究中进一步验证.

关键词:

抗中性粒细胞质抗体相关的血管炎.活检是为了检查生物质.磁共振成像技术磁共振成像技术肌肉,骨的组织.多膜炎结节症 (polyarteritis nodosa) 是一种多膜炎.血管炎是一种血管炎.

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