2型糖尿病患者和与代谢功能障碍相关的脂肪肝炎患者的微血管和宏血管并发症风险:回顾性队列研究
Semiu O Gbadamosi1, David Shi1, Abdalla Aly2
1Real-World Evidence, Clinical Data Science and Evidence, Novo Nordisk Inc., 800 Scudders Mill Rd, Plainsboro, NJ, 08536, USA.
概括
代谢功能障碍相关的脂肪肝炎 (MASH) 在2型糖尿病 (T2D) 患者中显著增加了微血管和宏血管并发症的风险. 综合管理对于这个高风险群体至关重要.
科学领域:
- 内分泌学和新陈代谢学
- 肝病学 肝病学是一种肝病学.
- 心血管疾病 心血管疾病
背景情况:
- 与代谢功能障碍相关的脂肪肝炎 (MASH) 和2型糖尿病 (T2D) 有着已知的负面相互作用.
- 同时存在的MASH对T2D并发症的影响需要进一步调查.
研究的目的:
- 为了评估共患MASH是否会加剧T2D并发症.
- 评估MASH与T2D患者微血管和宏血管并发症风险增加之间的关联.
主要方法:
- 一项使用Optum Clinformatics Data Mart数据库 (2016-2024) 的现实世界队列研究.
- 患有MASH和没有MASH的T2D患者的倾向性得分匹配 (1:1)
- 细灰竞争风险模型分析微血管和宏血管并发症风险.
主要成果:
- 与没有MASH的T2D患者相比,T2D和MASH患者的微血管 (sHR 1.19) 和宏血管并发症 (sHR 1.15) 的风险增加.
- 按血糖控制和年龄分层分析显示了类似的趋势.
- 该研究包括7396对微血管和6207对宏血管队列的匹配对.
结论:
- MASH与T2D的同时存在与微血管和宏血管并发症的风险更高有关.
- MASH似乎加速了T2D相关并发症的进展.
- 综合查和管理策略对于识别和治疗这种高风险T2D人群至关重要.
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