与隐性HBV感染相关的HLASNP的探索性分析:在中国献血者中进行的多中心病例对照研究

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Lin Zhou^1,2, Ying Yan^1,3, Huimin Ji^1,3

¹National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, 100730, P.R. China.

|December 24, 2025

概括

隐藏的乙型肝炎病毒感染 (OBI) 很难诊断. 主体遗传学,特别是HLA免疫反应,影响OBI风险,某些HLASNP和抗HBs水平影响敏感性.

科学领域:

免疫学免疫学免疫学
遗传学遗传学是一个
肝病学肝病学是一种肝病学.

背景情况:

隐性乙型肝炎病毒感染 (OBI) 由于无法检测到HBsAg,尽管可以检测到HBVDNA,但存在诊断挑战.
宿主遗传因素,特别是HLA介导的免疫调节,在OBI的发病过程中至关重要,但人们对其了解甚少.

研究的目的:

调查宿主遗传因素,特别是HLA单核酸多态 (SNP) 和OBI易感性之间的关联.
阐明OBI背后的免疫机制,并评估遗传标记物的预测价值.

主要方法:

在147名参与者 (74例OBI病例,73例慢性HBsAg+对照) 上进行了全外组测序.
分析重点是确定与OBI风险相关的HLASNP,并评估抗HBs标位和年龄的影响.

主要成果:

四个HLASNP与降低OBI易感性有关.
提出了一种双重免疫机制:HLA I类SNP损害了细胞毒性反应,而II类SNP破坏了幽默免疫力.
高抗HBs标位增加了不论基因型的OBI易感性;在50岁以上的个体中,遗传效应减少了.
整合HLA标志物改善了OBI易感性预测 (AUC0.93).

结论:

由HLA介导的免疫反应在OBI的发病过程中起着重要作用.
遗传标记,结合临床和血清学数据,可以提高预测OBI发展或进展到慢性感染.

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