生物标志物 生物标志物
Emma Pineau1, Keying Chen2, Margaret M Koletar2
1University of Toronto, Toronto, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
功能磁共振成像 (fMRI) 使用血液氧化水平依赖 (BOLD) 测量的大脑激活模式的可变性,随着年龄和认知障碍而增加. 这种变化可能作为阿尔茨海默病 (AD) 认知储备的神经生理学标记.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 认知科学 认知科学
背景情况:
- 阿尔茨海默病 (AD) 病理和认知功能,特别是认知储备之间的关系仍然不太清楚.
- 对刺激的反应中神经元的变化是一个已知的现象,但尚未在整个大脑范围内进行研究.
- 我们假设微观的神经元的变化导致宏观的血液氧化水平依赖 (BOLD) 功能磁共振成像 (fMRI) 激活模式的变化,可能反映了认知储备.
研究的目的:
- 通过使用BOLD fMRI来调查大脑全神经元激活模式的变化.
- 在老鼠AD模型中探索这种变化和认知储备之间的关系.
- 为了确定fMRI激活模式的变化是否是认知储备的神经生理学相关的.
主要方法:
- 在转基因Fischer 344大鼠 (TGF344-AD) 中使用延长的BOLD fMRI协议与重复的体感刺激,建模AD.
- 通过使用参数激活图和效果大小系列,逐试分析了voxel级响应变异性.
- 使用皮尔森相关性,量化激活模式的时间和空间变化,并根据年龄和认知状态对动物进行分类.
主要成果:
- 在年轻的老鼠,认知维持的老鼠和认知受损的老鼠中评估了大脑激活模式的变化.
- 大脑激活模式的变化量随着年龄和认知障碍程度的增加而增加.
- 对个体的分析显示了激活模式变异性的显著群体差异.
结论:
- 开发的BOLD fMRI测定对激活模式可变性的群体间差异敏感.
- 这种变化与研究的小鼠模型中的认知表现相关.
- fMRI激活模式的可变性显示出作为认知储备的神经生理学标记物的潜力.
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