生物标志物 生物标志物
Mathias Holsey Gramkow1, Frederikke Kragh Clemmensen1, Andreas Brink-Kjær2,3
1Danish Dementia Research Centre, Dept. of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
动态的瞳孔变化和夜间活动减少是阿尔茨海默病 (AD) 进展的有希望的数字生物标志物. 这些措施,从定量光反射瞳孔测量 (qLRP) 和动图,可以帮助早期AD预后和疾病跟踪.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 需要可访问的预后生物标志物来进行疾病修饰疗法.
- 定量光反射瞳孔测量 (qLRP) 和动图分别评估中脑功能和昼夜活动,两者都在AD中发生变化.
- 这项研究研究了qLRP和AD早期的动图的预后和疾病跟踪能力.
研究的目的:
- 确定qLRP和早期阿尔茨海默病中的动图的预后和疾病跟踪能力.
- 评估瞳孔和活动测量与临床,认知和神经成像进展的关联.
- 评估这些数字生物标志物用于AD预后和疾病监测.
主要方法:
- 一个单一中心的纵向队列研究包括86名阿尔茨海默病患者用于qLRP和58名用于动图,并进行了18-24个月的跟踪.
- 在基线和随访时进行了qLRP和动图;在1年随访时评估了临床进展,神经成像和认知衰退 (MMSE).
- 使用后勤回归和重复测量相关性来分析生物标志物与疾病进展之间的关联.
主要成果:
- 静止瞳孔直径的减少与更高的临床进展风险和认知衰退相关.
- 基线的瞳孔变化预测了神经成像进展.
- 减少夜间活动和每日内步骤的变化预测了临床进展和认知衰退.
结论:
- 动态的瞳孔变化和夜间活动减少是AD的有价值的数字生物标志物.
- 这些措施反映了兴奋状态和疾病进展的变化.
- qLRP和动图显示在缓解AD预后和疾病跟踪方面具有实用性.
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