生物标志物 生物标志物
Sara KamaliZonouzi1, Mobina Amanollahi1, Mahsa Dolatshahi2
1Tehran University of Medical Sciences, Tehran, Tehran, Iran (Islamic Republic of).
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
光学连贯断层扫描 (OCT) 可能有助于检测早期阿尔茨海默病 (AD) 通过识别视网膜变化,如质细胞内层 (GCIPL) 减少,与粉样β (Aβ) 脑负担相关. 需要进一步的研究来证实其临床效用.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 医疗成像医学成像
背景情况:
- 光学连贯性断层扫描 (OCT) 是诊断眼部疾病的成本效益高的工具.
- 它在检测大脑神经退行性疾病,如阿尔茨海默病 (AD) 的实用性正在调查中.
- 大脑粉样蛋白β (Aβ) 负担是阿尔茨海默病的一个关键生物标志物,通常用正子发射断层扫描 (PET) 来测量.
研究的目的:
- 系统地审查通过OCT量化的视网膜退化与通过PET测量的脑Aβ负担之间的联系.
- 探索OCT在识别早期AD标志物的潜力.
主要方法:
- 在PubMed,Embase,Scopus和Web of Science进行了系统的文献搜索.
- 包括11项涉及Aβ+和Aβ-受试者的研究,分析了OCT指标 (mRNFL,pRNFL,GCIPL) 和PET测量的Aβ负担.
- 数据提取和合成由两位作者独立进行.
主要成果:
- 该综述包括221名Aβ+和535名Aβ-受试者,包括认知正常,临床前阿尔茨海默病和认知受损组.
- 两项研究发现与Aβ病理相关的RNFL显著减少;七项研究发现非显著的变化.
- 四项研究报告了与Aβ病理相关的GCIPL显著减少;六项研究发现了非显著的变化.
结论:
- 视网膜变化与Aβ状态之间的关联目前尚不确定.
- 通过OCT检测到的视网膜变化,特别是GCIPL减少,可能有助于早期检测AD和Aβ阳性.
- 需要进一步的标准化研究来验证OCT在AD诊断中的临床潜力.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
511
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511