生物标志物 生物标志物
Suzanne E Schindler1, Anna Hofmann2, Madeline Paczynski3
1Washington University in St. Louis, St. Louis, MO, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
对阿尔茨海默病 (AD) 病理学的高精度血液测试显示出有希望. PrecivityAD2血液测试显示与CSF和PET扫描有很强的一致性,支持其用于指导抗粉样蛋白治疗.
科学领域:
- 神经学 神经学
- 生物标志物发现发现
背景情况:
- 华盛顿大学记忆诊断中心 (MDC) 每年评估大约4000名患者的记忆和认知问题.
- MDC使用血液生物标志物来评估阿尔茨海默病 (AD) 病理学,并确定适用于抗粉样蛋白疗法的资格.
研究的目的:
- 在临床环境中评估C2N诊断PrecivityAD2血液测试的性能.
- 评估PrecivityAD2测试与已建立的诊断方法 (如CSF分析和粉样蛋白PET扫描) 的一致性.
主要方法:
- 这项研究包括143名患有认知问题的患者,他们接受了PrecivityAD2血液测试.
- PrecivityAD2测试测量酸化陶和Aβ42/Aβ40的比率,以产生一个粉样蛋白概率得分2 (APS2).
- 21名患者的子组也接受了CSF或粉样蛋白PET测试以进行比较.
主要成果:
- 在143名患者中,76%的患者通过PrecivityAD2.2.测试呈阳性.
- 在21名患者的子组中,PrecivityAD2与CSF或PET相比显示了100%的正预测值和83%的负预测值.
- 所有15名通过PrecivityAD2呈阳性的患者也通过CSF或PET呈阳性.
结论:
- PrecivityAD2血液测试在识别粉样蛋白病理方面表现出高准确性.
- 这些发现支持使用准确的血液生物标志物测试来指导高临床阿尔茨海默病可能性的患者开始抗粉样蛋白治疗.
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