生物标志物 生物标志物
Patrick J Smith1, Kim G Johnson2, Heidi L Roth3
1University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
良好的感官和身体功能与更好的认知表现和阿尔茨海默病和相关痴呆症 (ADRD) 生物标志物有关. 这些发现凸显了感官和身体健康对整个生命周期的大脑健康的重要性.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 感官和身体功能下降与阿尔茨海默氏症和相关痴呆症 (ADRD) 的风险增加有关.
- 关于感官/身体功能,ADRD生物标志物和年轻和中年成年人的认知之间的联系的研究有限.
研究的目的:
- 调查感觉和身体功能,ADRD大脑脊髓液 (CSF) 生物标志物和认知功能之间的关联.
- 在跨越广泛年龄段的成年人队列中检查这些关系.
主要方法:
- 利用杜克-UNC ADRC的243名参与者的数据,其中162人正在接受CSF生物标志物评估.
- 评估视觉 (视觉敏度测试),听觉 (QuickSIN,听力测量) 和身体功能 (握力,上下测试).
- 用于认知领域 (执行,语言,视觉空间功能 - ELVF;记忆) 的因素分析和一般线性模型来分析关联,控制共变量.
主要成果:
- 更好的听力和视力与改善的记忆和ELVF认知表现相关.
- 提高听力与更高的Aβ42/40比率和更低的p-tau181水平有关.
- 改善的步行速度与更好的记忆和ELVF,更高的Aβ42/40和更低的NfL相关. 更好的握力与改善的ELVF相关.
结论:
- 感官和身体功能与认知功能和ADRD生物标志物有关,跨越各种成人年龄.
- 这些关系似乎独立于人口和临床因素.
- 建议在更大,更多样化的队列中进行进一步的复制,以确认发现并探索特定年龄的影响.
相关概念视频
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