生物标志物 生物标志物
Katrina A Wugalter1, Rebecca C Thurston2, Minjie Wu2
1Department of Psychology, University of Illinois Chicago, Chicago, IL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
患有APOE4基因变异的中年女性在记忆任务期间,即使没有认知能力下降,也显示出大脑活动和连接能力降低. 这些早期的大脑变化可能会在阿尔茨海默氏症 (AD) 风险的后期认知影响之前发生.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 认知科学 认知科学
背景情况:
- APOE4基因型与神经成像差异有关,特别是在女性中,随着年龄的增长,影响变得更加明显.
- 中年是识别认知衰退早期风险因素的关键时期,因为APOE4基因型对女性大脑健康的影响在这个阶段是微妙的.
- 需要早期生物标志物来检测女性APOE4载体中的大脑漏洞.
研究的目的:
- 在认知正常的中年女性中,在文字编码过程中,调查APOE4相关的脑活性和海马功能连接的差异.
- 探索这些大脑模式与口头记忆表现和血阿尔茨海默病 (AD) 生物标志物的关联.
主要方法:
- 功能性磁共振成像 (fMRI) 用于评估中年妇女在口头编码任务期间的大脑激活和海马功能连接.
- 用通用心理生理相互作用 (PPI) 分析来检查功能连接,并对多次比较进行校正.
- 使用线性回归分析APOE4组差异,调整年龄,种族和教育.
主要成果:
- 在口头识别性能,口头记忆测量或血AD生物标志物方面,在APOE4载体和非载体之间没有发现显著差异.
- 与携带者相比,非APOE4携带者在口头编码期间在特定的大脑区域表现出更大的激活和海马体功能连接.
- 左下额头回环激活与口头记忆有积极的关联,左海马连接与较低的p-tau 181水平有关.
结论:
- 女性中年APOE4载体在文字编码过程中表现出与记忆相关区域的活性和连接性降低,尽管与非载体具有相似的认知和生物标志物概况.
- 观察到的功能性大脑模式可能是APOE4相关的大脑脆弱性的早期指标.
- 这些发现表明,与APOE4基因型相关的功能性大脑变化可能会在可检测的认知或血生物标志物变化之前表现出来,这突显了它们与AD病变的相关性.
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