生物标志物 生物标志物
Alex Choi1, Hemal Patel2, Sandra Stinnett3
1Duke University School of Medicine, Durham, NC, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
与非载体相比,APOE ε4载体显示了视网膜微血管结构的差异,这可能表明早期阿尔茨海默病 (AD) 生物标志物. 阿尔茨海默病患者有明显的视网膜变化,表明疾病进展不同.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 遗传学 是一个遗传学.
背景情况:
- 阿尔茨海默病 (AD) 是一种神经退行性疾病.
- APOE ε4等位基因是晚期发作的AD的重要遗传风险因素.
- 视网膜变化可能成为AD等神经退行性疾病的早期生物标志物.
研究的目的:
- 为了研究视网膜结构和微血管结构的差异.
- 将患有阿尔茨海默氏病 (AD) 的个体,APOE ε4 携带者和非APOE ε4 携带者进行比较.
- 在视网膜中识别潜在的早期AD生物标志物.
主要方法:
- 光学连贯断层扫描 (OCT) 血管学用于分析视网膜血管密度 (VD) 和 perfusion密度 (PD).
- 测量包括周毛细管输液密度 (CPD) 和视网膜厚度参数 (RNFL,GC-IPL,CST).
- 没有包括患有糖尿病,青光眼或视网膜病理的参与者;应用了年龄和性别调整的通用估计方程.
主要成果:
- 与非载体相比,APOE ε4载体的PD和内环VD显著低于6mm的PD和内环VD.
- 与e4非携带者相比,患有AD的个体具有显著较低的CST,6mm圆PD,6mm圆VD和6mm内环VD.
- 与E4携带者和非携带者相比,AD患者表现出显著更高的周周毛囊性CPD.
结论:
- APOE ε4载体可能在视网膜微血管中表现出早期的AD生物标志物迹象,即使没有临床症状.
- 视网膜微血管结构的差异表明,在AD频谱中作为生物标志物具有潜在的实用性.
- 建议进行纵向研究,以进一步阐明这些视网膜生物标志物在AD进展中的作用.
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