Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

511
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Intraindividual cognitive variability predicts amyloid beta, tau PET, and dementia conversion in Down syndrome: a potential marker of cognitive resilience.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Inflammation Associated With Obesity, Aging, and Amyloid Burden in Adults With Down Syndrome.

Obesity (Silver Spring, Md.)·2026
Same author

Do white matter hyperintensities account for the relationship between discrimination and memory?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Dataset for selecting surrogates of emerging biothreat pathogens in laboratory research.

Scientific data·2026
Same author

Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome.

Neurology·2026
Same author

The association between APOE 𝜀4 carrierships and the detection of amyloid positivity using an Alzheimer's disease proteomic blood test in asymptomatic Down syndrome.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Patrick J Lao1,2, Anna C Smith1, Natalie C Edwards1

  • 1Columbia University Irving Medical Center, New York, NY, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

一些患有唐氏综合征 (DS) 的成年人抵抗阿尔茨海默病 (AD) 生物标志物. 保持认知稳定的老年DS个体表现出较低的粉样蛋白和白质过强度 (WMH),而低粉样蛋白的人则减少了tau和微血.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

699

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

699

科学领域:

  • 神经退行性疾病 神经退行性疾病
  • 遗传学与衰老的关系
  • 生物标志物发现发现

背景情况:

  • 阿尔茨海默病协会研究框架认为,所有患有唐氏综合征 (DS) 的成年人都会患上阿尔茨海默病 (AD).
  • 然而,一些患有DS的老年人并没有表现出AD生物标志物或认知能力下降,尽管有遗传倾向.
  • 这项研究调查了DS个体的脑血管和负担,这些个体的粉样蛋白水平低于预期.

研究的目的:

  • 为了探索与唐氏综合征的老年人之间和脑血管疾病负担的差异.
  • 确定导致AD生物标志物发育在DS群体内变化的因素.
  • 为了比较认知稳定的DS个体和粉样蛋白积累较低的个体的生物标志物概况.

主要方法:

  • 利用了来自阿尔茨海默氏症生物标志物联盟-唐氏综合征 (ABC-DS) 研究的259名患有DS的成年人的数据.
  • 评估参与者使用血管MRI (WMH,PVS,心脏病发作,微型血液),粉样蛋白PET和蛋白PET.
  • 根据认知稳定性,与阿尔茨海默病发病相对的年龄以及粉样蛋白PET残留物进行分类.

主要成果:

  • 认知稳定的DS老年人具有较低的粉样蛋白和后部白质过强度 (WMH).
  • 粉样蛋白水平在最低的第五百分位数中的个体表现出减少的积和更少的微型血液.
  • 在DS中,与年龄相关的认知稳定性与AD生物标志物和脑血管变化的独特模式有关.

结论:

  • 患有DS的老年人的认知稳定性与较低的粉样蛋白和后部WMH有关.
  • 在老年DS个体中,持续的低粉样蛋白水平与降低的病理和微型血液相关.
  • 需要进一步的研究来发现影响DS生物标志物和临床变异性的保护因素.