主观认知投诉和认知衰退在MAUCO基于人口的潜在队列中
Javiera Leniz1,2, Laura A Huidobro2,3, Sandra Cortés1,2
1School of Public Health, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Journal of Alzheimer's disease : JAD
|December 24, 2025
概括
主观认知投诉 (SCC) 与 benzodiazepines 和抗抑郁药等药物有关. 使用认知评估早期识别SCC和认知衰退,可以指导痴呆症的预防策略.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 主观认知投诉 (SCC) 可能表明痴呆和阿尔茨海默病的早期阶段.
- 关于拉丁美洲人口中SCC和认知衰退的研究有限.
- MAUCO队列研究解决了智利的这一差距.
研究的目的:
- 调查与SCC发病率相关的社会人口统计和临床因素.
- 为了确定智利成年人口认知衰退的预测因素.
- 为认知障碍提供有针对性的预防性干预信息.
主要方法:
- 在智利,基于人口的前性研究 (MAUCO队列).
- 包括38-74岁的成年人,进行基线和后续认知评估.
- 使用了SCC问卷,迷你心理状态检查 (MMSE) 和多变量考克斯回归.
主要成果:
- 高龄,使用二,使用抗抑郁药和抑郁症状与新的SCC相关.
- 增加药物使用和基线SCC预测认知能力下降.
- 没有基线SCC的参与者中有16.8%患有SCC;12.6%的正常MMSE患者表现出认知能力下降.
结论:
- bensodiazepine 和抗抑郁药的使用是与SCC发病率相关的关键因素.
- 主观认知投诉和MMSE得分是认知衰退的重要预测因素.
- 整合SCC和认知评估可以优化预防策略.
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