Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

854
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
854
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

609
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
609
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

722
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
722

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

ECCO Guidelines on the Prevention, Diagnosis, and Management of Infections in Inflammatory Bowel Disease.

Journal of Crohn's & colitis·2026
Same author

Dupilumab for Eosinophilic Esophagitis in Adolescents and Adults: Real-World Outcomes Across Different Dosing Regimens from the EoE CONNECT Registry.

The American journal of gastroenterology·2026
Same author

Clinical features and therapeutic requirements of perianal disease in adult patients with ulcerative colitis: the PERICO study of the ENEIDA registry.

Inflammatory bowel diseases·2026
Same author

Allergen Immunotherapy for the Treatment of Eosinophilic Esophagitis. An EAACI Task Force Systematic Review.

Clinical and translational allergy·2026
Same author

Authors' reply: Therapeutic management and risk of colectomy in patients with acute severe ulcerative colitis and previous exposure to anti-tumor necrosis factor drugs: a comparative study of GETECCU.

Journal of Crohn's & colitis·2026
Same author

Real-World Effectiveness of Risankizumab in Refractory Crohn's Disease: The RISANCROHN Study From the ENEIDA Registry.

Alimentary pharmacology & therapeutics·2026

相关实验视频

Updated: Jan 7, 2026

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.5K

综合多奥米分析确定了变化的结肠刷边界形状作为微观结肠炎的关键特征.

Danila Guagnozzi1,2,3,4, Ana Maria Gonzalez-Castro1,2,4, Yamile Zabana4,5

  • 1Laboratory of Neuro-immuno-gastroenterology, Vall d'Hebron Institut de Recerca, Barcelona, Spain.

United European gastroenterology journal
|December 24, 2025
PubMed
概括

微观性结肠炎 (MC) 涉及改变的结肠上皮细胞,影响刷边缘结构和蛋白质表达. 这些发现为MC病原和潜在的诊断生物标志物提供了新的见解.

关键词:
刷边界边界 刷边界边界结质结肠炎的发生.淋巴细胞性结肠炎显微型大肠炎的发生微型微型微型微型.

更多相关视频

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
10:33

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

11.4K
Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.7K

相关实验视频

Last Updated: Jan 7, 2026

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.5K
Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
10:33

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

11.4K
Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.7K

科学领域:

  • 胃肠病学 胃肠病学
  • 细胞生物学 细胞生物学
  • 炎症性肠道疾病研究研究

背景情况:

  • 微观性结肠炎 (MC),包括淋巴细胞性结肠炎 (LC) 和质结肠炎 (CC),是一种日益严重的炎症性肠病.
  • 它的确切原因尚不清楚,但结肠上皮质屏障功能受损可能使抗原暴露,引发炎症.

研究的目的:

  • 为了研究结肠表皮在微观结肠炎中的作用.
  • 将LC和CC患者的上皮细胞变化与对照组进行比较.

主要方法:

  • 从LC,CC,IBS-D和健康受试者的结肠活检对对转录和蛋白质组分析.
  • 皮质超结构性检查和评估布德塞诺治疗对CC皮质结构的影响.

主要成果:

  • 患有MC的患者表现出参与细胞粘附和actin细胞骨架组织的蛋白质的改变表达.
  • 质结肠炎 (CC) 呈现较短,较少的微型瘤,在布索尼德后部分改善;淋巴细胞结肠炎 (LC) 减少了微型瘤数量.
  • 在CC中观察到便频率和SPATN1/ATP8B1蛋白水平之间存在负相关性.

结论:

  • 在LC和CC中的结肠上皮表现出分子失调和异常的刷边缘超结构.
  • 这些发现增强了对MC病原学的理解,并建议用于诊断和治疗的潜在生物标志物.