生物标志物 生物标志物
1National Institute of Mental Health and Neurosciences, Bengaluru, India.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
使用伪连续动脉旋转标记 (pCASL) 的输液成像显示,阿尔茨海默病 (AD) 患者的叶和叶的脑血流 (CBF) 减少. 这突显了pCASL在诊断AD和理解神经退行症方面的潜力.
科学领域:
- 神经成像是一种神经成像.
- 脑血管生理学 脑血管生理学
- 神经退行性疾病 神经退行性疾病
背景情况:
- 大脑血流 (CBF) 对于理解阿尔茨海默病 (AD) 病理生理学至关重要.
- 输液成像,特别是伪连续动脉旋转标记 (pCASL),提供了一种非侵入性的方法来测量CBF.
研究的目的:
- 评估pCASL在阿尔茨海默病患者的诊断潜力.
- 为了将pCASL的发现与AD中已知的神经退行模式相关联.
主要方法:
- 一项前性,横截面的观察性研究包括25名被诊断患有AD的患者.
- pCASLMRI作为患者MRI检查的一部分进行.
- 使用Cortex_ID进行大脑分片进行了详细分析.
主要成果:
- 在pCASLMRI上观察到的低 perfusion 主要是在叶和叶中,反映了大脑外细胞缩.
- 在后侧环状回形 (双侧),前以及上/下叶中观察到显著的低 perfusion.
- 这些发现与阿尔茨海默病相关的神经退行现象的已知模式一致.
结论:
- pCASL在诊断阿尔茨海默病方面显示出显著的潜力.
- 该研究证实了叶和叶中普遍存在的低 perfusion,与DMN中断和AD病理学相一致.
- 建议采用标准化的pCASL协议和多模式方法,以获得强大的生物标志物开发和早期AD诊断.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516