Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

miR-4485-5p regulates the progression of periodontitis by targeting CDK9.

Odontology·2026
Same author

A Hybrid Experimental and in silico Platform for ITPK1 Chemical Probe Discovery.

SLAS discovery : advancing life sciences R & D·2026
Same author

The mechanism of action and therapeutic potential of macrophages in osteoporosis: from polarization balance to targeted regulation.

Frontiers in immunology·2026
Same author

Investigating the effects and underlying mechanisms of glycosylation sites on the immunogenicity of COVID-19 vaccines.

Signal transduction and targeted therapy·2026
Same author

Reengineering Aligned D-Orbital Energy Levels in FeMn Dual-Atom Nanozyme Inhibits Pyroptosis for Effective Alleviation of Inflammatory Diseases.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

The Genetics of TDP-43 Type C Neurodegeneration: A Whole-Genome Sequencing Study and Literature Review.

Neurology. Genetics·2026

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Dillan Patel1, Michael H Malek-Ahmadi2,3,4, Brandon Pitts5

  • 1Rice University, Houston, TX, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

具有APOE e4和MTHFR 677T等位基因的个体更有可能获得粉样蛋白阳性结果,这表明阿尔茨海默病 (AD) 的潜在治疗点.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 心血管科学 心血管科学

背景情况:

  • MTHFR基因的677T和1298C等位基因与homocysteine处理和阿尔茨海默氏症 (AD) 和心血管疾病的风险增加有关.
  • 血管因素在阿尔茨海默氏症的发病过程中发挥着作用.
  • 研究基因与环境的相互作用对于理解AD风险至关重要.

研究的目的:

  • 检查MTHFR等位基相互作用 (677T,1298C) 与APOE e4以及白质超强度体积 (WMHV) 和粉样蛋白阳性之间的关联.
  • 为了确定潜在的遗传和血管风险因素,粉样蛋白积累在认知不受损的老年人.

主要方法:

  • 来自阿尔茨海默病神经成像计划 (ADNI) 的341名认知正常 (CU) 个体的分析.
  • 粉样蛋白-PET SUVR用于确定粉样蛋白阳性.
  • 后勤回归模型评估了MTHFR等位基因的贡献和与APOE e4状态和WMHV的相互作用,并根据年龄和性别进行调整.

主要成果:

  • 无论是MTHFR 1298C还是677T等位基因,都没有对粉样蛋白阳性产生显著的主要影响.
  • 与APOE e4和WMHV的MTHFR 1298C等位基因相互作用与粉样蛋白阳性无关.
  • 在MTHFR 677T等位基因与APOE e4载体状态 (OR=4.53,p=0.04) 之间,在粉样蛋白阳性方面发现了显著的相互作用.

结论:

  • 携带APOE e4和MTHFR 677T等位基因的认知能力正常的个体更有可能是粉样蛋白阳性.
  • 针对涉及APOE e4和MTHFR 677T的血管相关途径,可能为缓解AD中的粉样蛋白病理提供治疗策略.