生物标志物 生物标志物
Dillan Patel1, Michael H Malek-Ahmadi2,3,4, Brandon Pitts5
1Rice University, Houston, TX, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
具有APOE e4和MTHFR 677T等位基因的个体更有可能获得粉样蛋白阳性结果,这表明阿尔茨海默病 (AD) 的潜在治疗点.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 心血管科学 心血管科学
背景情况:
- MTHFR基因的677T和1298C等位基因与homocysteine处理和阿尔茨海默氏症 (AD) 和心血管疾病的风险增加有关.
- 血管因素在阿尔茨海默氏症的发病过程中发挥着作用.
- 研究基因与环境的相互作用对于理解AD风险至关重要.
研究的目的:
- 检查MTHFR等位基相互作用 (677T,1298C) 与APOE e4以及白质超强度体积 (WMHV) 和粉样蛋白阳性之间的关联.
- 为了确定潜在的遗传和血管风险因素,粉样蛋白积累在认知不受损的老年人.
主要方法:
- 来自阿尔茨海默病神经成像计划 (ADNI) 的341名认知正常 (CU) 个体的分析.
- 粉样蛋白-PET SUVR用于确定粉样蛋白阳性.
- 后勤回归模型评估了MTHFR等位基因的贡献和与APOE e4状态和WMHV的相互作用,并根据年龄和性别进行调整.
主要成果:
- 无论是MTHFR 1298C还是677T等位基因,都没有对粉样蛋白阳性产生显著的主要影响.
- 与APOE e4和WMHV的MTHFR 1298C等位基因相互作用与粉样蛋白阳性无关.
- 在MTHFR 677T等位基因与APOE e4载体状态 (OR=4.53,p=0.04) 之间,在粉样蛋白阳性方面发现了显著的相互作用.
结论:
- 携带APOE e4和MTHFR 677T等位基因的认知能力正常的个体更有可能是粉样蛋白阳性.
- 针对涉及APOE e4和MTHFR 677T的血管相关途径,可能为缓解AD中的粉样蛋白病理提供治疗策略.
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