生物标志物 生物标志物
Michelle Cohn1, Alyssa Weakley2, Alyssa M Lanzi3
1University of California, Davis, Davis, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
在与语音助理交谈时,语音速率可能表明认知状态. 在技术导向的任务中讲话速度较慢与认知障碍有关,这表明一种潜在的生物标志物.
科学领域:
- 认知科学 认知科学
- 计算语言学 计算语言学
- 老年学是指老年学的学科.
背景情况:
- 语音技术的交互是常见的,促使人们对认知状态检测进行研究.
- 语音速率是认知障碍的潜在生物标志物,但之前的研究重点是人类定向的语音.
- 与人类相比,个人在与技术互动时会改变言语速度.
研究的目的:
- 调查语音速率作为认知障碍生物标志物的可靠性,用于技术导向的语音任务.
- 确定在使用语音助理时,神经类型个体和认知障碍者之间是否存在语音速度差异.
主要方法:
- 语音助理系统 (VAS) 库的分析,包括89名参与者 (65-94岁) 具有不同的认知状态 (根据MoCA分数进行评估).
- 使用Prat测量发言级别的语音速度 (每秒音节),模拟混合效应回归.
- 包括MoCA得分,性别,年龄,老年抑郁症评分,通用焦虑评分和语音技术经验作为预测因素.
主要成果:
- 在Alexa指导的命令中,更高的MoCA分数与更快的语音速度相关 (p <0.01).
- 女性表现出比男性更快的言语速度 (p < 0.05).
- 在神经型成年人和轻度认知障碍或痴呆症患者之间观察到言语速率分布的显著重叠.
结论:
- 语音频率降低与技术导向命令中的认知障碍有关.
- 较慢的语音速度可能作为一个敏感的,虽然不是特定的,行为生物标志物用于认知状态.
- 需要进一步的研究来完善语音速率作为认知衰退的诊断工具.
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