多重复合社区检测功能连接网络中的子组识别
IEEE transactions on bio-medical engineering
|December 24, 2025
概括
这项研究引入了一种新方法,使用fMRI数据的多重网络来找到精神病障碍患者的亚组. 这种方法揭示了不同的临床模式,帮助精准医学提供量身定制的治疗.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 数据科学数据科学数据科学
背景情况:
- 了解精神病障碍异质性对于精准医学至关重要.
- 目前使用功能磁共振成像 (fMRI) 的方法经常分析单个功能网络,限制了洞察力.
- 存在着对探索跨多个功能网络关系的方法的需求.
研究的目的:
- 通过整合跨功能网络信息,开发一种用于识别精神障碍患者子组的新方法.
- 为了利用多重网络构建和社区检测进行子组分析.
- 提高对精神病障碍异质性的理解,并推进精准医学.
主要方法:
- 从多个主体静止状态fMRI数据衍生出的功能连接网络构建的多重网络.
- 应用基于多重网络的社区检测来识别跨网络的共同和私有社区.
- 使用模拟和464名精神病患者的现实fMRI数据验证了该方法.
主要成果:
- 提出的方法有效地确定了精神病患者的临床相关子组.
- 确定的子组在功能领域显示出显著的差异,例如默认模式网络 (DMN) 和前额前皮层 (antPFC).
- 功能领域的差异与不同的临床评分相关,与先前的研究保持一致.
结论:
- 新的多重网络方法成功地揭示了精神疾病中具有临床意义的子组.
- 这种方法增强了对精神病障碍中的个体变异性和异质性的理解.
- 这些发现为开发定制治疗和推进精神病学精准医学提供了框架.
更多相关视频
07:12Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time
Published on: July 1, 2014
12.7K
08:36Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
Published on: March 21, 2019
7.6K
相关概念视频
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
03:21RNA-seq
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases.
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
01:24Tagging and Fusion Proteins
Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
01:25Rapid Identification of Pathogens
MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...