生物标志物 生物标志物
Thanakit Pongpitakmetha1,2,3,4, Thanapoom Taweephol5, Nattanich Pornteparak6
1Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
血质纤维酸蛋白 (GFAP) 与大脑小血管疾病 (CSVD) 的负担相关,特别是在非阿尔茨海默氏症患者中.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 生物标志物 生物标志物
背景情况:
- 大脑小血管疾病 (CSVD) 是血管认知障碍和痴呆症 (VCID) 的首要原因,也是阿尔茨海默病 (AD) 的潜在共同病理.
- 血质纤维酸蛋白 (GFAP) 可能表明星细胞症,这是一种涉及到CSVD和AD的过程.
- 了解CSVD生物标志物与血GFAP之间的关系对于诊断和管理认知衰退至关重要.
研究的目的:
- 在记忆诊所队列中评估CSVD的神经成像生物标志物和血GFAP水平之间的相关性.
- 调查这种相关性是否在患有阿尔茨海默病 (AD) 和没有阿尔茨海默病 (AD) 的患者之间有所不同.
- 探索AD生物标志物对CSVD和血GFAP之间的关系的影响.
主要方法:
- 从114名参与者收集了记忆诊所的临床信息和血生物标志物.
- 使用已确定的标准 (CSF Aβ 42/p-tau181比或Aβ PET) 将患者分为AD和非AD组.
- 使用基于MRI的STRIVE-2标准评估CSVD并计算综合总CSVD得分;使用非参数统计数据分析相关性.
主要成果:
- 在整体队列和非AD组中,总体CSVD得分和血GFAP之间发现了显著的正相关性.
- 这种相关性在调整血p-tau 217,一个关键的AD生物标志物后,在整个队列中大大加强.
- 特定的CSVD神经成像生物标志物与血GFAP呈现出正相关性,尽管并非在所有标志物中普遍存在.
结论:
- 在没有AD的个体中,CSVD负担和血GFAP之间的相关性比AD的个体更强.
- 对像p-tau 217这样的AD生物标志物的调整增强了CSVD得分和血GFAP之间观察到的相关性.
- 由于病理机制的重叠,单独的血GFAP可能在反映AD患者的CSVD负担方面存在局限性;建议进一步研究VCID的其他液体生物标志物.
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