生物标志物 生物标志物
Rachel R Wu1, Elaine Zhu1, Christina L Bi1
1NYU Grossman School of Medicine, New York, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
手术可能会增加老年人的阿尔茨海默病生物标志物,神经认知障碍 (NCD) 在25%的患者中出现手术后. 生物标志物变化,如UHCL-1,表明NCD患者的神经元损伤.
科学领域:
- 老年医学 老年医学
- 神经科学是一个神经科学.
- 手术研究的研究.
背景情况:
- 人口老龄化 (40%的手术患者≥65岁) 面临神经认知障碍 (NCD) 风险增加.
- 神经炎症和血脑屏障变化与与年龄相关的认知衰退有关.
- 调查外科手术期间的变化对于了解老年手术患者的认知结果至关重要.
研究的目的:
- 在接受手术的老年人中分析外科手术期间血液生物标志物变化.
- 为了将生物标志物改变与神经认知测试结果相关联.
- 评估手术对65岁及以上患者认知领域的影响.
主要方法:
- 接受关节整形手术的患者 (≥65岁) 用T-cog和T-MoCA评估了基线认知.
- 采集了手术前和手术后的血液样本,以分析生理变化.
- 手术后3个月重复进行神经认知评估;NCD被定义为> -1 SD Z-score变化.
主要成果:
- 25%的患者 (11/44) 在手术后3个月内发展出非传染性疾病,男性患病率更高.
- 在患有NCD的患者中观察到较低的手术前抗炎IL-4水平.
- 在手术后,NCD患者的UHCL-1水平较高,而非NCD患者的IL-10水平较高;两组都增加了T-tau和p-Tau 181.
结论:
- 手术可以增强阿尔茨海默病的生物标志物,包括Aβ42 / p-Tau181比率,特别是在非NCD患者中.
- 手术后升高的UHCL-1证实了NCD患者的神经元损伤.
- 需要对更大的样本大小进行进一步的研究,以确认生物标志物趋势的发现.
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