生物标志物 生物标志物
Haoteng Tang1, Kun Zhao2, Guodong Liu2
1University of Texas Rio Grande Valley, Edinburg, TX, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
阿尔茨海默病对不同种族的大脑网络的影响不同. 我们的研究揭示了西班牙裔和白人个体之间明显的结构性大脑差异,这对于包容性诊断至关重要.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 医学科学 医学科学 医学科学
背景情况:
- 阿尔茨海默氏症 (AD) 导致大脑网络的重大破坏,因种族而异.
- 研究这些差异对于理解人口统计学对神经退行症的影响至关重要.
- 使用扩散MRI进行结构性大脑网络分析,可以了解特定种族的变化.
研究的目的:
- 调查与阿尔茨海默病或没有阿尔茨海默病的西班牙裔和白人个体的特定种族结构性大脑网络变化.
- 为了确定AD进展过程中不同种族之间的关键大脑区域和连接.
- 发现潜在的结构性大脑生物标志物受种族影响.
主要方法:
- 来自OASIS和BrainLat数据集的扩散MRI数据被用于构建结构性大脑网络 (106个ROI).
- 拉普拉斯规范化标准化连接值,用于跨主题的可比性.
- 基于网络的统计分析确定了在认知正常 (NC) 和AD人群中区分种族群体 (西班牙裔与白人) 的显著子网络和ROI.
主要成果:
- 在认知正常的个体中,167个显著的连接和76个ROI显示出种族差异,西班牙裔的前极连接更强.
- 在阿尔茨海默病患者中,32个显著的联系和35个ROI在种族之间存在差异.
- 在AD-White和AD-Hispanic群体之间观察到角,状皮质和海马体区域的明显连接性模式.
结论:
- 特定于种族的结构性大脑网络差异存在于认知正常和阿尔茨海默氏症患者群体中.
- 扩散MRI显示了与种族相关的显著连接组变异.
- 研究结果强调了在神经退行性疾病研究和临床策略中考虑人口差异的重要性.
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