生物标志物 生物标志物
Ramiro Eduardo Rea Reyes1, Rachael E Wilson2, Julie E Oomens3
1Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
较高的体重与较低的血pTau217水平有关,这是阿尔茨海默病 (AD) 的关键生物标志物. 根据体量进行调整,可以通过血液检测改善早期AD检测.
科学领域:
- 神经退行性疾病的神经退行性疾病
- 发现生物标志物的发现.
- 阿尔茨海默病的诊断阿尔茨海默病的诊断.
背景情况:
- 血pTau217是阿尔茨海默病 (AD) 中粉样蛋白病理学的验证生物标志物.
- 诸如体重 (体量) 等因素可能会影响pTau217测量的准确性.
- 了解肥胖的影响对于早期阿尔茨海默病检测研究至关重要.
研究的目的:
- 为了研究体积对血pTau217度的影响.
- 评估肥胖对其他与阿尔茨海默病相关的血液生物标志物的影响.
- 用 pTau217.7 来确定体量对粉样蛋白阳性的分类准确性的影响.
主要方法:
- 对阿尔茨海默病研究队伍中746名参与者的纵向血样本的分析.
- 血生物标志物的测量包括pTau217,GFAP,NfL,Aβ40和Aβ42.
- 使用混合玛回归来建模生物标记水平,包括年龄,体量,APOEε4载体和性别.
主要成果:
- 增加的体量与血pTau217水平在粉样蛋白蓄积体和非蓄积体中降低了4 - 5%.
- 由于肥胖而导致的pTau217的减少相当于大约3.25年延迟达到肥胖个体的诊断值.
- 对于GFAP和NfL观察到类似的减少,但对于Aβ42/Aβ40比率没有.
结论:
- 肥胖显著影响了AD关键生物标志物的血水平,包括pTau217,GFAP和NfL.
- 在分析中考虑身体质量可能会提高基于血的AD生物标志物测量的精度.
- 根据体量进行调整可以显著改善使用血液检测早期检测阿尔茨海默病的情况.
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