Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Relationship Between Routine Preoperative Chest CT-Based Cardiac Parameters and Recanalization After Mechanical Thrombectomy in Patients with Acute Ischemic Stroke.

Journal of clinical medicine·2026
Same author

Neuron-derived mitochondrial DNA (mtDNA) activates microglia via the Z-DNA binding protein 1 (ZBP1)-mediated pathway in mild traumatic brain injury.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Seasonal variations in outcomes following spontaneous intracerebral hemorrhage: a case control study.

BMC neurology·2026
Same author

An orthogonal RNA aptamer for targeted RNA regulation in phase-separated subcellular compartments.

Nature communications·2026
Same author

Exploring the PLD1-tau interaction in Frontotemporal Dementia.

bioRxiv : the preprint server for biology·2026
Same author

Regional correlates of tau pathology and synaptic function in primary age-related tauopathy.

Journal of Alzheimer's disease : JAD·2026

相关实验视频

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Jutatip Guptarak1, Batbayar Tumurbaatar1, Michela Marcatti1

  • 1University of Texas Medical Branch, Galveston, TX, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

在患有阿尔茨海默氏症神经病理学 (NDAN) 的非痴呆个体中发现的非毒性陶寡合体 (tauO) 可能会对认知能力下降提供弹性. 将有毒的tauO转化为不那么有害的形式可能是阿尔茨海默病 (AD) 的治疗策略.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 生物化学 生物化学

背景情况:

  • 阿尔茨海默病 (AD) 是导致痴呆的主要原因,其特点是有毒的寡合物 (tauO).
  • 患有广泛的AD病理但没有痴呆症 (非痴呆症与阿尔茨海默氏症神经病理学 - NDAN) 的个人表现出认知性.
  • 这种弹性表明,在NDAN病例中,tauO可能会以无毒的方式传播.

研究的目的:

  • 为了研究来自AD患者和NDAN个体的大脑衍生型陶寡合体 (BDTO) 的独特特性.
  • 为了比较AD-BDTO与NDAN-BDTO的神经毒性和细胞效应.

主要方法:

  • 从AD和NDAN大脑中分离和描述BDTO.
  • 实验室试验 (LTP,细胞存活率) 和体内研究使用小鼠脑内内注射.
  • 分析自标志物,抗氧化剂反应,微质细胞和行为测试 (新型物体识别).

主要成果:

  • 与AD-BDTO相比,NDAN-BDTO显著降低了突触和神经元毒性.
  • 注射NDAN-BDTO的小鼠表现出保存的自,强大的抗氧化反应和增加的微质细胞化.
  • 在行为测试中,注射NDAN-BDTO的小鼠表现出更好的记忆保留.

结论:

  • NDAN大脑含有无毒的tauO,它在不引起神经元死亡或认知衰退的情况下传播.
  • 治疗策略可以专注于将有毒的陶转化为不那么有害的形式,以阻止AD的进展.
  • 研究NDAN tauO中的潜在突变或结构修改可能会揭示新的弹性机制.