生物标志物 生物标志物
Gulam Mahfuz Chowdhury1, Khalid Saifullah1, Arnold M Evia2
1Illinois Institute of Technology, Chicago, IL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
动脉健康和老化大脑 (AHAB) 研究发现,动脉健康和老化大脑 (AHAB) 评分与阿尔茨海默氏症病理学无关,但与大脑小血管疾病 (CSVD) 中的轴突损伤有关. 这支持AHAB作为CSVD的特定标志物.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 生物标志物研究 生物标志物研究
背景情况:
- 内动脉硬化是大脑小血管疾病 (CSVD) 的关键因素,影响大脑健康和认知.
- 动脉健康和老化大脑 (AHAB) 评分是用于 in-vivo 动脉样硬化检测的新型MRI标记.
- 化217 (p-tau217) 和神经丝光链 (NfL) 等等离子体生物标志物分别表明阿尔茨海默病 (AD) 和轴突损伤.
研究的目的:
- 为了研究动脉健康和老化大脑 (AHAB) 评分和血生物标志物p-tau217和NfL之间的关联.
- 为了确定AHAB分数是否受到阿尔茨海默氏症病理学的影响.
- 为了评估AHAB分数和轴突损伤之间的关系.
主要方法:
- 包括202名从四项衰老队列研究中没有或轻度认知障碍的参与者.
- 使用MPRAGE,FLAIR和DTI序列进行了体内MRI (3Tesla),以计算AHAB分数.
- 测量了血p-tau217和NfL水平;线性回归分析了关联,控制了人口统计和扫描参数.
主要成果:
- 在AHAB得分和p-tau217水平之间没有发现显著的关联,表明与阿尔茨海默氏症病理学无关.
- 在AHAB得分和NfL水平之间观察到强烈的正相关性,这表明与CSVD相关的轴突损伤存在联系.
结论:
- 在老年人中,阿尔茨海默氏症病理不影响AHAB分数.
- 较高的AHAB分数与轴突损伤的增加相关,如NfL水平升高所示.
- 这些发现支持AHAB作为动脉样硬化和CSVD的特定MRI标记物的实用性.
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