生物标志物 生物标志物
Alexis B Kazen1, Laura Glass Umfleet1, Fatima A Aboulalazm1
1Medical College of Wisconsin, Wauwatosa, WI, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
包括细菌和病毒在内的肠道微生物组的变化与轻度认知障碍中的认知衰退和脑血管变化有关. 特定的肠道微生物和菌体与大脑功能和健康有关.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 阿尔茨海默病 (AD) 与肠道失调和脑血管疾病有关,但它们的相互作用尚未完全理解.
- 研究肠道微生物群在轻度认知障碍 (MCI) 中的作用对于了解AD病理生理学至关重要.
研究的目的:
- 探索肠道微生物群组成,脑血管功能和患有amnestic轻度认知障碍 (aMCI) 个体的认知状态之间的关系.
- 为了比较aMCI患者和认知不受损的对照者之间的肠道微生物群概况和脑血管指标.
主要方法:
- 14名aMCI患者和10名对照人提供了便样本用于16S和猎枪元基因组测序.
- 使用MRI评估脑血管反应 (CVR),脑血流 (CBF) 和动脉传输时间 (ATT).
- 斯皮尔曼相关性分析检查了微生物种类,脑血管指标和认知得分之间的联系.
主要成果:
- 不同的细菌和病毒种群使aMCI患者与对照人群有所区别.
- 支持炎症的肠道细菌与认知和脑血管功能有负相关;有益的细菌显示出积极的关联.
- 像Alistipes indistinctus和Bilophila wadsworthia这样的特定微生物,以及B. wadsworthia菌体,在aMCI中与较差的认知和脑血管结果有关.
结论:
- 与对照组相比,aMCI 个体表现出改变的肠道微生物组.
- 在aMCI中,细菌和病毒肠道微生物都与认知和神经血管功能显著相关.
- 了解这些肠-大脑-血管轴相互作用可以为未来的MCI和AD研究提供信息.
相关概念视频
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The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
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These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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