Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same authorSame journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Infarct-associated oligoclonal T cell expansion in chronic experimental stroke across age, sex, and models.

Experimental neurology·2026
Same author

Circulating palmitoleic acid is associated with cerebral glucose metabolism in healthy middle-aged individuals: results from the Progression of Early Subclinical Atherosclerosis prospective cohort study.

The American journal of clinical nutrition·2026
Same author

CXCL12 levels correlate with reduced stroke severity and lower risk of hemorrhagic transformation in stroke patients.

Frontiers in cardiovascular medicine·2026
Same author

Uncovering the causal link between cerebral glucose metabolism and cognitive function in Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same author

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression.

The FEBS journal·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Marta Casquero-Veiga1,2, Carlos Ceron2, Nicolás Lamanna-Rama2,3

  • 1Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Madrid, Madrid, Spain.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
概括
此摘要是机器生成的。

研究人员开发了新的PET生物标志物,以检测阿尔茨海默病 (AD) 模型中的大脑微血栓. 这些工具可视化纤维素和血小板,帮助早期诊断和针对阿兹海默症患者的个性化抗凝药疗法.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经科学是一个神经科学.
  • 生物标志物开发 生物标志物开发
  • 医疗成像医学成像

背景情况:

  • 阿尔茨海默氏病 (AD) 与前血栓状况有关,由大脑纤维素和血小板活性增加而证明.
  • 这种促血栓的环境有助于早期的AD病理,如低输液和血脑屏障的破坏.
  • 非侵入性检测大脑微型血栓对于识别可能受益于抗凝药治疗的患者至关重要.

研究的目的:

  • 开发和验证新的正子发射断层扫描 (PET) 生物标志物,用于在AD小鼠模型中非侵入性检测大脑微血栓.
  • 评估向纤维素和血小板的可行性,以成像大脑中的血栓活性.

主要方法:

  • 通过将纤维素结合探针 (FBP) 和反-CD41抗体附着在转环子素 (TCO) 上,合成了两个PET探针.
  • 这些TCO功能化的探针与标记为氨酸 (TZ) 的68Ga-化剂DOTA (用于纤维素) 或标记为68Ga的氧化铁纳米粒子 (用于血小板) 反应.
  • 在AD小鼠 (TgCRND8) 和动脉压碎损伤模型中进行了PET/CT成像和ex vivo生物分布研究.

主要成果:

  • 开发的两种PET生物标志物都在动脉压伤模型中表现出特异性,显示了血管损伤部位的痕迹积累.
  • 在AD小鼠的大脑中观察到68Ga-Tz吸收的增加,无论探针是否准纤维素或CD41.
  • 活体研究证实了体内发现,验证了AD小鼠大脑中增加的吸收.

结论:

  • 成功开发了两个可行的神经成像策略,以评估AD的小鼠模型中的血栓前状态.
  • 这些新的PET生物标志物为早期诊断和个性化抗凝剂治疗策略提供了潜在的窗口,以减轻AD的进展.