生物标志物 生物标志物
Averi Giudicessi1,2, Elouise A Koops2,3,4, Nikole A Bonillas Félix2
1Boston University, Boston, MA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
老年拉丁裔的白质完整性随着年龄的增长而下降,在时间通路中观察到性别特异性差异. 这种下降与认知表现有关,这表明扩散指标可以预测早期的神经退行.
科学领域:
- 神经成像是一种神经成像.
- 老年学是一门学科.
- 认知神经科学 认知神经科学
背景情况:
- 白质的恶化是神经退行性疾病的早期指标,通常在认知症状之前.
- 大脑管道易受早期病理变化的影响,影响区域间的沟通.
- 了解老年人群中早期的神经退行至关重要.
研究的目的:
- 在社区居住的老拉丁裔中检查白质微观结构与认知表现的关系.
- 为了确定与年龄相关的变化和白质完整性的性别特异性差异.
- 探索扩散指标作为认知衰退早期生物标志物的潜力.
主要方法:
- 扩散权重成像 (DWI) 用于评估122名未受损的老拉丁裔成年人的白质微观结构.
- 对于10个主要的白质区域,提取了分数异构性 (FA) 和平均扩散性 (MD).
- 全球认知表现 (MMSE) 被测量,对年龄,性别和教育进行回归分析.
主要成果:
- 在下部和上部纵向囊中发现了与年龄相关的FA减少.
- 增加的MD被观察到在前面的thalamic辐射,下面的前后带,和环膜环膜圈.
- 认知表现与海马环带白质完整性相关;在上纵向囊中注意到性别差异.
结论:
- 白质完整性容易受到与年龄相关的衰退的影响,在时间路径上有显著的性别特异性差异.
- 扩散指标,特别是在海马环膜,显示潜在的早期生物标志物认知衰退.
- 这些发现增强了对拉丁裔人口认知衰老机制的理解,以及与年龄相关的大脑完整性的变化.
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