生物标志物 生物标志物
Bénédicte Maréchal1,2,3, Tommaso Di Noto1,2,3, Thanchanok Jomsak4
1Swiss Innovation Hub, Siemens Healthineers International AG, Lausanne, Switzerland.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
在MRI上的海马缩与阿尔茨海默氏病 (AD) 诊断的PET扫描中的低代谢有很强的相关性. 海马体积显示出良好的区分能力,可能作为一个查工具,如果PET是不可用的.
科学领域:
- 神经成像是一种神经成像.
- 人工智能的人工智能
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 海马缩和低代谢是早期阿尔茨海默病 (AD) 诊断的关键神经成像生物标志物.
- 人工智能 (AI) 能够对脑MRI进行定量自动体积分析,以客观评估脑缩.
- 这项研究将MRI中的海马体积与早期AD诊断的18F-FDG PET低代谢进行比较.
研究的目的:
- 为了比较来自MRI的海马体积与18F-FDG PET低代谢.
- 评估这些生物标志物在早期诊断阿尔茨海默病的有用性.
- 评估海马体体积与低代谢之间的诊断区分能力.
主要方法:
- 22名阿尔茨海默症患者和26名对照人群在3T MR-PET系统上接受了结构性MRI和18F-FDG PET扫描.
- 一个深度学习工具 (MorphoBox) 从MRI量化了正常化的大脑体积;p-mod软件从PET计算了SUVR.
- 执行了皮尔森相关性和ROC分析,以比较成像模式并评估歧视.
主要成果:
- 在多个大脑区域,包括海马 (p < 0.001) 中,在AD和对照组之间观察到SUVR的显著差异.
- 在SUVR和正常的大脑体积之间发现了强烈的相关性 (ρ=0.60-0.73),特别是在海马,额叶,叶和叶.
- 海马相对体积显示出良好的区分能力,AUC为0.79.
结论:
- 在阿尔茨海默病中,海马体体积 (MRI) 和低代谢 (FDG PET) 之间存在强烈的相关性.
- 人工智能驱动的海马体积测量可以作为一种有价值的查工具,特别是当PET访问有限时.
- 在这项研究中,海马体积测量显示出优越的区分能力,这需要在更大的队列中进行进一步的研究.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
746
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
746
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
511
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
511