生物标志物 生物标志物
Camilo Bermudez1, Ekaterina I Hofrenning1, Jeffrey L Gunter2
1Mayo Clinic, Rochester, MN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
脑脊液 (CSF) 动态的障碍,如正常压力水脑 (NPH),可以影响阿尔茨海默病 (AD) 血液测试. 血中异常的粉样β 42 (Aβ42) 度与扩大的脑下脑空间水脑 (DESH) 有关,但p-tau217仍然可靠.
科学领域:
- 神经学 神经学
- 生物标志物发现发现
- 神经成像是一种神经成像.
背景情况:
- 同时存在的阿尔茨海默氏症 (AD) 和脑脊液 (CSF) 动态障碍,如正常压力水头 (NPH),可以改变CSF Aβ42水平,使AD生物标志物的解释复杂化.
- 脊髓动力学对基于血的AD生物标志物的影响仍然在很大程度上未被探索.
- 这项研究研究了MRI检测到的不成比例扩大的下大脑空间水脑症 (DESH) 和基于质谱的血AD生物标志物之间的关联.
研究的目的:
- 为了确定通过质谱测量的血阿尔茨海默氏病 (AD) 生物标志物是否与在MRI上发现的不成比例扩大的甲状腺下空间头 (DESH) 有关.
- 评估CSF动态对血AD生物标志物的可靠性的影响.
主要方法:
- 利用了509名梅奥诊所老龄化研究参与者的数据,包括MRI,Aβ PET扫描和血生物标志物 (酸化蛋白217,Aβ40,Aβ42).
- 进行了年龄调整后勤回归,以评估血生物标志物水平异常 (p-Tau 217,%p-tau217,Aβ42,Aβ42/40比) 与DESH存在之间的关联.
- DESH分类是基于一个经过验证的自动化MRI算法.
主要成果:
- 32名参与者被确定为DESH阳性.
- 不正常的血Aβ42水平与DESH显著相关 (OR,2.56;p=0.018).
- 在DESH和异常的血p-tau217或%p-tau217.7之间没有发现显著的关联. 亚组分析显示,异常的Aβ42与阳性粉样蛋白PET相结合与DESH有关.
结论:
- 血Aβ42水平受到脑流动力学的影响,特别是DESH,这与之前的脑流研究一致.
- 血p-tau217表现出对DESH的强度,这表明它适合作为CSF动态异常的个体的生物标志物.
- 对于p-tau217.7,建议在患有更严重的CSF动态障碍的人群中进行进一步验证.
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