生物标志物 生物标志物
Federica Anastasi1,2,3, Armand González Escalante1,2,4, Pol Segura-Retana1
1Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
血蛋白可以预测患有阿尔茨海默病 (AD) 风险的个体的认知衰退. 性别特定的蛋白质关联突出了个性化风险分层策略的需要.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 蛋白质组学是指蛋白质组学.
背景情况:
- 早期检测阿尔茨海默病 (AD) 标志是可能的与血生物标志物.
- 由于结果的变化和缺乏预后标志物,预测风险人群的认知衰退具有挑战性.
- 这项研究侧重于与无症状,AD风险个体的认知轨迹相关的基线血蛋白,包括性别特异性因素.
研究的目的:
- 为了确定与长期认知轨迹相关的基线血蛋白在患有AD风险的无症状个体中.
- 调查性别特异性蛋白质与认知变化的关联.
- 探索可预测认知衰退的蛋白共同表达模块.
主要方法:
- 在410个认知不受损的个体中,在7.5年内分析了认知轨迹 (修改的临床前阿尔茨海默氏症认知复合物,mPACC).
- 使用Olink Explore和SomaScan平台评估认知轨迹和血蛋白之间的关联.
- 利用性别相互作用分析和加权基因共同表达网络分析 (WGCNA) 来识别认知衰退的预测因素.
主要成果:
- 10个Olink和26个SomaScan蛋白与认知轨迹显著相关.
- 确定了重要的性蛋白相互作用,预测了认知变化.
- 一个与神经系统发育相关的蛋白质模块与衰退状态有关.
结论:
- 血蛋白显示出潜在的预后标记,用于预测无症状AD风险个体的认知轨迹.
- 性别特定的蛋白质关联强调了个性化风险评估的重要性.
- 这些发现可能有助于制定针对阿尔茨海默病预防的有针对性的干预措施.
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