生物标志物 生物标志物
Mei Pu1,2,3, Qianhua Zhao4,5
1Fudan University, Shanghai, Shanghai, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
血液TRPC6mRNA水平显示出作为新的阿尔茨海默病 (AD) 生物标志物具有前途. 在AD患者中较低的TRPC6mRNA水平表明它有可能用于可访问和具有成本效益的AD查.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 分子生物学分子生物学
背景情况:
- 目前的阿尔茨海默氏病 (AD) 诊断依赖于昂贵和侵入性的PET成像或CSF测试以检测粉样β (Aβ) 和tau.
- 对于用于AD查和诊断的可访问和具有成本效益的生物标志物有着至关重要的需求.
研究的目的:
- 调查血液中短暂受体潜在正规6 (TRPC6) mRNA水平作为阿尔茨海默病 (AD) 生物标志物的诊断效用.
- 评估TRPC6mRNA水平与阿尔茨海默病患者的Aβ沉积和大脑体积的相关性.
主要方法:
- 1,100名参与者 (366名阿尔茨海默病患者,734名认知正常) 被录取.
- 通过PET成像评估Aβ沉积;通过MRI评估大脑体积;在所有参与者中测量TRPC6mRNA水平.
- 在PET成像上通过Aβ阳性证实了AD诊断.
主要成果:
- 与对照组相比,AD患者的血液TRPC6mRNA水平显著降低 (p < 0.0001).
- TRPC6 mRNA水平显示出高诊断准确度 (AUC = 0.935) 识别阿兹海默症患者.
- 与Aβ沉积和大脑体积相关的TRPC6mRNA水平,表现优于其他血生物标志物,除了p-tau217.7.
结论:
- 血液TRPC6mRNA水平显示出在识别AD患者的诊断实用性非常好.
- TRPC6 mRNA为阿兹海默症诊断提供了一个可行的,可扩展的和具有成本效益的血液生物标志物.
- TRPC6 mRNA有可能作为阿尔茨海默病的独立诊断指数.
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