针对小肠的长效口服胰岛素配方,基于人工牛奶蛋白纳米粒子
Anbu Mozhi Thamizhchelvan1, Yuancheng Li1,2, Jonathan Padelford2
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
ACS applied bio materials
|December 24, 2025
概括
这项研究开发了一种口服胰岛素配方,使用甲酸与甲酸的素纳米载体. 新的口服胰岛素有效降低血糖并改善生物可用性,为糖尿病管理提供了注射有前途的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 内分泌学 在内分泌学.
背景情况:
- 皮下胰岛素注射是糖尿病的标准,但面临着不良遵守和低血糖等挑战.
- 口服胰岛素配方旨在改善粘附性并模仿自然胰岛素释放,但仍面临生物可用性问题.
研究的目的:
- 开发和评估一种新的口服胰岛素配方,使用素纳米载体共同封装胰岛素和甲酸盐.
- 评估口服胰岛素配方的稳定性,释放动力学,生物可用性和血糖控制功效.
主要方法:
- 胰岛素和甲酸盐 (C10) 被联合封装成基于素的纳米载体 (casNP).
- 配方的稳定性在模拟的胃和腹液体中进行了测试.
- 肠道囊的ex vivo研究优化了C10度.
- 在小鼠的口服中评估了药理动力学和药理动力学参数.
主要成果:
- casNP/胰岛素/C10在模拟的胃液中表现出稳定性,并在骨液中释放.
- 在小鼠的口服中,小肠输送达到了10.8%,生物利用率达到了18.1%.
- 口服的casNP/胰岛素/C10表现出与皮下胰岛素Aspart可比的血糖控制,作用时间较长,没有低血糖.
结论:
- 素纳米载体有效地通过口服输送胰岛素,提高生物可用性和疗效.
- 这种口服胰岛素配方显示出改善糖尿病管理和患者遵从性的巨大潜力.
- 需要进一步的临床研究来验证这种有前途的口服胰岛素输送系统.
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