生物标志物 生物标志物
Matthew Jy Kang1,2, Dhamidhu Eratne1,2, Christa Dang3
1University of Melbourne, Parkville, VIC, Australia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
概括
阿尔茨海默病 (AD) 中的冷漠和焦虑与较高水平的神经退行性标记物有关,包括血p-tau181和神经丝光链 (NfL). 这些发现表明这些常见症状的潜在治疗目标.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
背景情况:
- 在阿尔茨海默氏病 (AD) 中,冷漠和情感神经精神症状 (NPS) 是常见的.
- 阿尔茨海默病中这些症状的神经生物学基础仍然不清楚.
- 了解这些联系对于开发向治疗至关重要.
研究的目的:
- 调查神经退行症和病理的血生物标志物与冷漠和情感症状之间的关联.
- 为了在轻度认知障碍 (MCI) 和AD痴呆症患者中探索这些关系.
主要方法:
- 781名患有MCI和AD痴呆症的参与者的纵向分析来自阿尔茨海默病神经成像计划 (ADNI).
- 在四年内每年收集血液样本.
- 使用神经精神病学面试 (NPI) 评估神经精神病学症状,并通过混合效应模型分析生物标志物轨迹.
主要成果:
- 血p-tau181和神经纤维光链 (NfL) 水平升高与MCI和AD痴呆症中的冷漠和焦虑相关.
- 无动于衷显示了NfL增加的显著更高的速度,这表明神经退行加速.
- 这些发现将特定的血生物标志物与阿尔茨海默氏症的关键神经精神病症状联系起来.
结论:
- 漠不关心和焦虑可能是TAU病理增加和AD中神经退行性负担增加的指标.
- 这些症状突出了在阿尔茨海默病中干预的潜在治疗目标.
- 像p-tau181和NfL这样的等离子体生物标志物可以帮助理解和管理AD中的NPS.
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